Evaluation of circulating serum 3 types of microRNA as biomarkers of oral squamous cell carcinoma; A pilot study

Karimi, A. and Bahrami, N. and Sayedyahossein, A. and Derakhshan, S. (2019) Evaluation of circulating serum 3 types of microRNA as biomarkers of oral squamous cell carcinoma; A pilot study. Journal of Oral Pathology and Medicine.

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Abstract

Introduction: The microRNAs are molecules which have important biologic role and play key point in cancers. The aim of present study was to determine the miR-21, miR-24, and miR-29a expression in serum of patients with oral squamous cell carcinoma. Materials and methods: Blood samples were obtained from 40 patients (20 in cases and 20 in control group) to determine the miR-21, miR-24, and miR-29a expressions by using real-time PCR and �CT. Results: Mean miR-29a was �2.28 ± 2.15 and 5.61 ± 2.38 in case and control groups, respectively. The miR-21 was 6.90 ± 3.86 and �0.88 ± 2.31 in case and control groups, respectively. According to the results, miR-24 was 2.13 ± 2.89 and �0.35 ± 2.44 in case and control, respectively. A significant difference was observed on miR-21, miR-24, and miR-29a between two groups (P <.05). The results obtained by t test showed miR-21 and miR-24 were higher and miR-29a was lower in plasma of oral squamous cell carcinoma patients and this differences were significant (P <.05). Conclusion: These results suggested miR-21, miR-24, and miR-29a in serum of patients with oral squamous cell carcinoma comparing with normal group can be used as potent markers for carcinoma detection and also may be a potentially therapeutic approach in the future. More longitudinal studies with larger samples are necessary to confirm these findings. © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Item Type: Article
Additional Information: cited By 0
Subjects: Dentistry
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Dentistry > Department of Dental and Oral Surgery
Depositing User: ART . editor
Date Deposited: 28 Dec 2019 15:03
Last Modified: 28 Dec 2019 15:03
URI: http://eprints.kaums.ac.ir/id/eprint/4801

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