Neuropathological and genomic characterization of glioblastoma-induced rat model: How similar is it to humans for targeted therapy?

Sharifzad, F. and Yasavoli-Sharahi, H. and Mardpour, S. and Fakharian, E. and Nikuinejad, H. and Heydari, Y. and Mardpour, S. and Taghikhani, A. and khellat, R. and Vafaei, S. and Kiani, S. and Ghavami, S. and �os, M. and Noureddini, M. and Ebrahimi, M. and Verdi, J. and Hamidieh, A.A. (2019) Neuropathological and genomic characterization of glioblastoma-induced rat model: How similar is it to humans for targeted therapy? Journal of Cellular Physiology, 234 (12). pp. 22493-22504.

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DOI: UNSPECIFIED

Abstract

Glioblastoma multiforme (GBM) is a unique aggressive tumor and mostly develops in the brain, while rarely spreading out of the central nervous system. It is associated with a high mortality rate; despite tremendous efforts having been made for effective therapy, tumor recurrence occurs with high prevalence. To elucidate the mechanisms that lead to new drug discovery, animal models of tumor progression is one of the oldest and most beneficial approaches to not only investigating the aggressive nature of the tumor, but also improving preclinical research. It is also a useful tool for predicting novel therapies' effectiveness as well as side effects. However, there are concerns that must be considered, such as the heterogeneity of tumor, biological properties, pharma dynamic, and anatomic shapes of the models, which have to be similar to humans as much as possible. Although several methods and various species have been used for this approach, the real recapitulation of the human tumor has been left under discussion. The GBM model, which has been verified in this study, has been established by using the Rat C6 cell line. By exploiting bioinformatic tools, the similarities between aberrant gene expression and pathways have been predicted. In this regard, 610 common genes and a number of pathways have been detected. Moreover, while magnetic resonance imaging analysis enables us to compare tumor features between these two specious, pathological findings provides most of the human GBM characteristics. Therefore, the present study provides genomics, pathologic, and imaging evidence for showing the similarities between human and rat GBM models. © 2019 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: aspm protein; aurka protein; aurkb protein; birc5 protein; Bub1 related protein; bub1b protein; cdca8 protein; cell cycle protein 20; cenpe protein; checkpoint kinase 1; cyclin A2; cyclin B1; cyclin dependent kinase 1; dlgap5 protein; exo1 protein; fn1 protein; kif11 protein; kif20a protein; kif23 protein; kif2c protein; mad2l1 protein; minichromosome maintenance protein 2; polo like kinase 4; protein p53; Rad51 protein; top2a protein; ttk protein; tumor protein; ube2c protein; unclassified drug; unindexed drug, animal cell; animal experiment; animal model; apparent diffusion coefficient; Article; C6 cell line (glioma); calcium signaling; controlled study; DNA replication; down regulation; extracellular matrix; focal adhesion; GABAergic system; gene expression; gene expression profiling; gene identification; gene ontology; genomics; glioblastoma; glutamatergic synapse; histopathology; human; human cell; MAPK signaling; molecularly targeted therapy; neuroimaging; neuropathology; nonhuman; nuclear magnetic resonance imaging; oocyte maturation; Pi3K/Akt signaling; priority journal; protein protein interaction; rat; rat model; synapse vesicle; tobacco dependence; tumor growth; tumor model; upregulation
Subjects: Neuroscience
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Applied Cell Sciences
Depositing User: ART . editor
Date Deposited: 28 Dec 2019 15:00
Last Modified: 28 Dec 2019 15:00
URI: http://eprints.kaums.ac.ir/id/eprint/4800

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