Chlorella vulgaris supplementation attenuates the progression of liver fibrosis through targeting TGF-β-signaling pathway in the CCl4-induced liver fibrosis in rats

Mohseni, R. and Arab Sadeghabadi, Z. and Karimi, J. and Gholami, H. and Ghasemi, H. and Ghadimipour, H.R. and Kheiripour, N. (2019) Chlorella vulgaris supplementation attenuates the progression of liver fibrosis through targeting TGF-β-signaling pathway in the CCl4-induced liver fibrosis in rats. Toxin Reviews.

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Abstract

The purpose of this study is to investigate the molecular mechanism underlying hepatoprotective effect of Chlorella vulgaris extract (CVE). The administration of both doses of CVE attenuated liver damage and decreased serum markers and oxidative stress parameters dramatically. Also, CVE treatment downregulated hepatic gene expression of collagen type1 (Col1a1), fibronectin (Fn1), transforming growth factor-beta 1 (Tgfb1), transforming growth factor-beta receptor 2 (Tgfbr2) and SMAD family member 3 (Smad3) significantly. Hepatic level of TGF-β1 protein was decreased by CVE treatment significantly. CVE supplementation restraints liver fibrosis progression through amelioration of oxidative stress status and targeting TGF-β signaling pathway. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: cited By 0
Subjects: Immunology and Microbiology
Divisions: Faculty of Medicine > Basic Sciences > Department of Microbiology & Immunology
Depositing User: ART . editor
Date Deposited: 25 Dec 2019 15:54
Last Modified: 25 Dec 2019 15:54
URI: http://eprints.kaums.ac.ir/id/eprint/4795

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