Effects of melatonin supplementation on hormonal, inflammatory, genetic, and oxidative stress parameters in women with polycystic ovary syndrome

Jamilian, M. and Foroozanfard, F. and Mirhosseini, N. and Kavossian, E. and Aghadavod, E. and Bahmani, F. and Ostadmohammadi, V. and Kia, M. and Eftekhar, T. and Ayati, E. and Mahdavinia, M. and Asemi, Z. (2019) Effects of melatonin supplementation on hormonal, inflammatory, genetic, and oxidative stress parameters in women with polycystic ovary syndrome. Frontiers in Endocrinology, 10 (MAY).

[img] Text

Download (698kB)
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....


Purpose: The aim of the current study was to evaluate the effect of melatonin administration on clinical, hormonal, inflammatory, and genetic parameters in women with polycystic ovarian syndrome (PCOS). Methods: The present randomized, double-blinded, placebo-controlled clinical trial was conducted among 56 patients with PCOS, aged 18�40 years old. Subjects were randomly allocated to take either 5 mg melatonin supplements (n = 28) or placebo (n = 28) twice a day for 12 weeks. Results: Melatonin administration significantly reduced hirsutism (β �0.47; 95 CI, �0.86, �0.09; P = 0.01), serum total testosterone (β �0.11 ng/mL; 95 CI, �0.21, �0.02; P = 0.01), high-sensitivity C-reactive protein (hs-CRP) (β �0.61 mg/L; 95 CI, �0.95, �0.26; P = 0.001), and plasma malondialdehyde (MDA) levels (β �0.25 μmol/L; 95 CI, �0.38, �0.11; P < 0.001), and significantly increased plasma total antioxidant capacity (TAC) levels (β 106.07 mmol/L; 95 CI, 62.87, 149.28; P < 0.001) and total glutathione (GSH) (β 81.05 μmol/L; 95 CI, 36.08, 126.03; P = 0.001) compared with the placebo. Moreover, melatonin supplementation downregulated gene expression of interleukin-1 (IL-1) (P = 0.03) and tumor necrosis factor alpha (TNF-α) (P = 0.01) compared with the placebo. Conclusions: Overall, melatonin administration for 12 weeks to women with PCOS significantly reduced hirsutism, total testosterone, hs-CRP, and MDA, while increasing TAC and GSH levels. In addition, melatonin administration reduced gene expression of IL-1 and TNF-α. Copyright © 2019 Jamilian, Foroozanfard, Mirhosseini, Kavossian, Aghadavod, Bahmani, Ostadmohammadi, Kia, Eftekhar, Ayati, Mahdavinia and Asemi.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: C reactive protein; glutathione; malonaldehyde; medroxyprogesterone; melatonin; nitric oxide; placebo; sex hormone binding globulin, adult; antioxidant assay; Article; biochemical analysis; blood sampling; body height; body weight; body weight change; cell isolation; controlled clinical trial; controlled study; dietary intake; double blind procedure; down regulation; female; gene expression; genetic parameters; hirsutism; hormone action; human; lymphocyte; major clinical study; outcome assessment; ovary polycystic disease; oxidative stress; physical activity; randomized controlled trial; real time polymerase chain reaction; RNA extraction; scoring system; testosterone blood level
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 28 Dec 2019 15:22
Last Modified: 28 Dec 2019 15:22
URI: http://eprints.kaums.ac.ir/id/eprint/4786

Actions (login required)

View Item View Item