Effects of synbiotic food consumption on glycemic status and serum hs-CRP in pregnant women: A randomized controlled clinical trial

Taghizadeh, M. and Asemi, Z. (2014) Effects of synbiotic food consumption on glycemic status and serum hs-CRP in pregnant women: A randomized controlled clinical trial. Hormones, 13 (3). pp. 398-406.

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Abstract

Objective: The aim of this study was to determine the effects of synbiotic food consumption on glycemic status and serum high sensitivity C-reactive protein (hs-CRP) levels of Iranian pregnant women. Design: This randomized placebo-controlled clinical trial was performed among 52 pregnant women, primigravida, aged 18-35 year old, in their third trimester. After a 2-wk run-in period, subjects were randomly assigned to consume either a synbiotic (n=26) or control food (n=26) for 9 weeks. The synbiotic food consisted of a probiotic Lactobacillus sporogenes (1�107 CFU), 0.04 g inulin as prebiotic with 0.38 g isomalt, 0.36 g sorbitol and 0.05 g stevia as sweetener per 1 g. Control food (the same substance without probiotic bacteria and inulin) was packed in identical 9-gram packages. Patients were asked to consume the synbiotic and control foods two times a day. Fasting blood samples were taken at baseline and after a 9-wk intervention for quantification of related factors. Results: Consumption of a synbiotic food did not show any significant change regarding the impact of insulin actions in the synbiotic group; nonetheless, compared to the control food, it resulted in a significant decrease in serum insulin levels (-0.26 vs. 6.34 μIU/mL, P=0.014) and HOMA-IR (-0.13 vs. 1.13, P=0.033), a significant difference in HOMA-B (5.30 vs. 34.22, P=0.040) and a significant rise in QUICKI score (0.002 vs. -0.02, P=0.022). Conclusions: Consumption of a synbiotic food for 9 weeks by pregnant women had beneficial effects on insulin actions compared to the control food, but did not affect FPG and serum hs-CRP concentrations.

Item Type: Article
Additional Information: cited By 6
Uncontrolled Keywords: C reactive protein; glucose; insulin; inulin; isomalt; placebo; sorbitol; sweetening agent; biological marker; C reactive protein; disaccharide; glucose blood level; insulin; inulin; prebiotic agent; probiotic agent; sorbitol; sugar alcohol; sweetening agent; synbiotic agent, adult; article; caloric intake; carbohydrate intake; cholesterol intake; controlled study; dietary fiber; fat intake; female; food composition; food intake; glucose blood level; human; insulin blood level; insulin resistance; Iran; Iranian people; Lactobacillus; Lactobacillus sporogenes; pregnant woman; primigravida; protein blood level; protein intake; randomized controlled trial; Stevia; third trimester pregnancy; adolescent; blood; classification; diet; glucose blood level; maternal nutrition; metabolism; nutritional status; physiology; pregnancy; time; treatment outcome; young adult, Adolescent; Adult; Biological Markers; Blood Glucose; C-Reactive Protein; Diet; Disaccharides; Female; Humans; Insulin; Inulin; Iran; Lactobacillus; Nutritional Status; Prebiotics; Pregnancy; Pregnancy Trimester, Third; Prenatal Nutritional Physiological Phenomena; Probiotics; Sorbitol; Stevia; Sugar Alcohols; Sweetening Agents; Synbiotics; Time Factors; Treatment Outcome; Young Adult
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 05 Mar 2017 08:38
Last Modified: 05 Mar 2017 08:38
URI: http://eprints.kaums.ac.ir/id/eprint/478

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