RETRACTED ARTICLE: Effect of l-citrulline supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials

Mahboobi, S. and Tsang, C. and Rezaei, S. and Jafarnejad, S. (2019) RETRACTED ARTICLE: Effect of l-citrulline supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials. Journal of Human Hypertension, 33 (1). pp. 10-21.

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Abstract

The objective of this study was to systematically investigate the efficacy of oral l-citrulline supplementation on systolic and diastolic blood pressure. Studies were identified by a search of electronic databases from inception to April 2018, and combined and stratified analyses were used. Fifteen trials were identified, and data from 424 participants were included. Pooled analysis showed significant reductions in systolic blood pressure by �7.54 mmHg (95 confidence interval (CI): �9.44, �5.63; P < 0.001, I2 = 14) and diastolic blood pressure by �3.77 mmHg (95 CI: �5.67, �1.86, P < 0.001, I2 = 42) following oral supplementation of l-citrulline or a watermelon extract. No changes were detected in controls. Significant heterogeneity (I2 = 42, P = 0.04) was found for diastolic blood pressure, and subgroup analysis showed significant improvements in systolic and diastolic blood pressure, particularly for study durations: �6 weeks, lower doses: �4 g/day, and in participants with higher baseline values: �130/85 mmHg. In conclusion, l-citrulline improves systolic and diastolic blood pressure and may be more efficacious in pre-hypertensive and hypertensive populations. © 2018, Springer Nature Limited.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: citrulline; plant extract, blood pressure; blood pressure measurement; diastolic blood pressure; drug effect; drug efficacy; human; meta analysis; randomized controlled trial (topic); Review; supplementation; systematic review; systolic blood pressure
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Biochemistry
Depositing User: ART . editor
Date Deposited: 29 Dec 2019 11:07
Last Modified: 29 Dec 2019 11:07
URI: http://eprints.kaums.ac.ir/id/eprint/4774

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