The effects of L-carnitine supplementation on glycemic control: A systematic review and meta-analysis of randomized controlled trials

Fathizadeh, H. and Milajerdi, A. and Reiner, Ž. and Kolahdooz, F. and Asemi, Z. (2019) The effects of L-carnitine supplementation on glycemic control: A systematic review and meta-analysis of randomized controlled trials. EXCLI Journal, 18. pp. 631-643.

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Abstract

The findings of trials investigating the effect of L-carnitine administration on glycemic control are controversial. This meta-analysis of randomized controlled trials (RCTs) was performed to explore the effects of L-carnitine intake on glycemic control. Two authors independently searched electronic databases including MEDLINE, EM-BASE, Cochrane Library, Web of Science, PubMed and Google scholar from 1990 until February 2019, in order to find relevant RCTs. 37 studies with 44 effect sizes met the inclusion criteria and were eligible for the meta-analysis. L-carnitine supplementation resulted in a significant reduction in fasting plasma glucose (FPG) (WMD:-4.57; 95 CI:-6.88,-2.25), insulin (WMD:-1.21; 95 CI:-1.85,-0.57), homeostatic model assessment for insulin resistance (HOMA-IR) (WMD:-0.67; 95 CI:-0.90,-0.44) and HbA1C concentrations (WMD:-0.30; 95 CI:-0.47,-0.13). L-Carnitine supplementation significantly reduced FPG, insulin, HOMA-IR, and HbA1c levels. © 2019, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: carnitine; glucose; hemoglobin A1c; insulin, Article; China; effect size; Egypt; fasting; glucose blood level; glycemic control; homeostasis model assessment; human; impaired glucose tolerance; India; Iran; Iraq; Italy; Japan; Korea; Lebanon; meta analysis; Mexico; randomized controlled trial (topic); Spain; systematic review; treatment duration; treatment outcome; United Kingdom; United States
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Biochemistry
Depositing User: ART . editor
Date Deposited: 29 Dec 2019 11:25
Last Modified: 29 Dec 2019 11:25
URI: http://eprints.kaums.ac.ir/id/eprint/4754

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