YKL-40 in Asthma and its Correlation with Different Clinical Parameters

Saba, M. and Sharif, M.R. and Akbari, H. and Nikoueinejad, H. and Jolfaii, M.R. (2014) YKL-40 in Asthma and its Correlation with Different Clinical Parameters. Iranian Journal of Allergy, Asthma and Immunology, 13 (4). pp. 271-277.

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It has been suggested that elevated serum level of YKL-40 could be a marker for asthma and its severity. Along with few published studies, we investigated its correlation with asthma and its severity as well as spirometric indices. 114 patients with asthma and 114 healthy controls underwent the assessment of serum level of YKL-40 (by ELISA) and spirometric indices. Pearson's coefficient determined the correlation between the variables and multivariate linear regression analysis was used for adjusting the effect of different probable confounding factors. Serum levels of YKL-40 were significantly higher in the asthmatic patients compared to those in healthy people (p<0.001). We also found a significant correlation between YKL-40 serum level and spirometric indices even after adjusting the effects of other variables. We report for the first time in an Iranian population that YKL-40 may be a good diagnostic marker of asthma in serum. Copyright© Summer 2014, Iran J Allergy Asthma Immunol. All rights reserved.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: biological marker; hydrolase; unclassified drug; YKL 40 protein; adipocytokine; CHI3L1 protein, human; lectin, adult; article; asthma; clinical feature; controlled study; correlational study; diagnostic test accuracy study; disease association; disease severity; enzyme linked immunosorbent assay; female; human; Iranian people; major clinical study; male; prognosis; protein blood level; sensitivity and specificity; spirometry; asthma; blood; forced expiratory volume; genetics; middle aged; pathophysiology; receiver operating characteristic, Adipokines; Adult; Asthma; Female; Forced Expiratory Volume; Humans; Lectins; Male; Middle Aged; ROC Curve
Subjects: Medicine
Divisions: Faculty of Medicine > Clinical Sciences > Department of Internal Medicine
Depositing User: editor . 2
Date Deposited: 05 Mar 2017 20:09
Last Modified: 05 Mar 2017 20:09
URI: http://eprints.kaums.ac.ir/id/eprint/466

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