Comparison of the effect of sertraline with behavioral therapy on semen parameters in men with primary premature ejaculation

Akasheh, G. and Sirati, L. and Noshad Kamran, A.R. and Sepehrmanesh, Z. (2014) Comparison of the effect of sertraline with behavioral therapy on semen parameters in men with primary premature ejaculation. Urology, 83 (4). pp. 800-804.

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Objective To investigate the effects of sertraline on semen parameters and comparison of its effect with behavioral therapy (BT) in men with primary premature ejaculation. Methods In this single-blinded clinical trial, a total of 60 married men with primary premature ejaculation were randomly divided into 2 groups: the sertraline group (n = 30, sertraline 25 mg/day for 1 week followed by 50 mg/day for 3 months) and the BT group (n = 30, using BT technique for 3 months). Semen analysis was applied, and the results were compared between groups before and 3 months after intervention. Results The significant reduction in sperm concentration (105/mL) and percentage of normal morphology was reported in sertraline group (P <.05). The percentage of sperm deoxyribonucleic acid fragmentation after intervention in sertraline group was significantly higher than BT group (P =.004). There was no significant change in semen parameters in patients treated using BT. Conclusion Our study revealed detrimental effects of sertraline on some semen parameters. It should particularly be considered in patients who are trying to conceive. It seems BT is a safe method without any side effect on semen analysis parameters. © 2014 Elsevier Inc. All Rights Reserved.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: DNA; sertraline, adult; article; behavior therapy; cell structure; comparative study; controlled clinical trial; controlled study; DNA fragmentation; drug effect; human; major clinical study; male; male genital tract parameters; married man; premature ejaculation; priority journal; semen analysis; single blind procedure; spermatozoon density; spermatozoon motility; young adult, Adolescent; Adult; Behavior Therapy; DNA Fragmentation; Humans; Male; Premature Ejaculation; Prevalence; Semen; Serotonin Uptake Inhibitors; Sertraline; Single-Blind Method; Spermatozoa; Time Factors; Treatment Outcome; Young Adult
Subjects: Medicine
Divisions: Faculty of Medicine > Clinical Sciences > Department of Psychiatry
Depositing User: editor . 2
Date Deposited: 05 Mar 2017 20:07
Last Modified: 05 Mar 2017 20:07

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