Epinecidin-1, a highly potent marine antimicrobial peptide with anticancer and immunomodulatory activities

Neshani, A. and Zare, H. and Akbari Eidgahi, M.R. and Khaledi, A. and Ghazvini, K. (2019) Epinecidin-1, a highly potent marine antimicrobial peptide with anticancer and immunomodulatory activities. BMC Pharmacology and Toxicology, 20 (1).

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Abstract

Background: Antibiotic-resistant pathogens are an emerging threat in this century. Epinecidin-1 is a multi-functional Antimicrobial Peptide (AMP) produced by Orange-spotted grouper (Epinephelus coioides) has been shown to have extensive potentials as an alternative for current antibiotics. Due to the huge costs for the study and the production of a new drug, if an antimicrobial peptide has other beneficial functions in addition to antimicrobial activities, it would be preferred. Methods: In this study, properties and applications of Epinecidin-1 were investigated and addressed comprehensively. To achieve this, the Google Scholar search engine and three databases of PubMed, Scopus, and Web of Science were used. Results: Epinecidin-1 is a cationic AMP with an alpha-helical structure. Seven functional usages of this peptide have been reported in the literature including antibacterial, antifungal, antiviral, antiprotozoal, anticancer, immunomodulatory, and wound healing properties. Moreover, this peptide has high potential to be used as an active ingredient in cleaning solutions as well as application in vaccine production. Conclusion: Due to significant antimicrobial activities tested on bacteria such as Staphylococcus aureus and Helicobacter pylori and also wound healing properties, Epi-1 has high potential to be considered as an important candidate for the production of new drugs and treatment of various infections including diabetic foot ulcer and peptic ulcer. Moreover, adjuvant-like properties of Epi-1 make it a suitable candidate for the studies related to an adjuvant. Other attractive properties such as anticancer effects have also been reported for this peptide which encourages further studies on this peptide. © 2019 The Author(s).

Item Type: Article
Additional Information: cited By 4
Uncontrolled Keywords: domestic chemical; epinecidin 1; polypeptide antibiotic agent; unclassified drug; vaccine, alpha helix; antibacterial activity; antifungal activity; antimicrobial activity; antineoplastic activity; antiprotozoal activity; antiviral activity; Article; cell membrane potential; cleaning; data base; diabetic foot; drug design; drug mechanism; drug use; Helicobacter pylori; human; immunomodulation; immunoregulation; infection; nonhuman; peptic ulcer; protein stability; protein structure; Staphylococcus aureus; vaccine production; wound healing
Subjects: Immunology and Microbiology
Divisions: Faculty of Medicine > Basic Sciences > Department of Microbiology & Immunology
Depositing User: ART . editor
Date Deposited: 30 Dec 2019 12:30
Last Modified: 30 Dec 2019 12:30
URI: http://eprints.kaums.ac.ir/id/eprint/4564

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