Protective effect of Zingiber officinale extract on rat testis after cyclophosphamide treatment

Mohammadi, F. and Nikzad, H. and Taghizadeh, M. and Taherian, A.A. and Azami-Tameh, A. and Hosseini, S.M. and Moravveji, S.A. (2014) Protective effect of Zingiber officinale extract on rat testis after cyclophosphamide treatment. Andrologia, 46 (6). pp. 680-686.

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Abstract

Summary: Decreasing the side effects of chemotherapy in testis has been the subjects of many studies. In this study, the protective effects of Zingiber officinale extract on rat testis were investigated after chemotherapy with cyclophosphamide. Histological and biochemical parameters were compared in cyclophosphamide-treated rats with or without ginger extract intake. Wistar male rats were randomly divided into four groups each 10. The control group received a single injection of 1 ml isotonic saline intraperitoneally. The Cyclophosphamide (CP) group received a single dose of cyclophosphamide (100 mg kg-1 BW) intraperitoneally. CP + 300 and CP + 600 groups received orally 300 or 600 mg of ginger extract, respectively, for a period of 6 weeks after cyclophosphamide injection. The morphologic and histological structure of the testis was compared in different groups of the rats. Also, factors like malondialdehyde, reactive oxygen species, total antioxidant capacity and testosterone level were assessed in blood serum as well. Our results showed that although ginger extract could not change testis weight, malondialdehyde (MDA) and ROS, but antioxidant and testosterone levels in serum were increased significantly. Also, an obvious improved histological change was seen in CP + 300 and CP + 600 groups in comparison with CP group. These protective effects of ginger on rat testis after cyclophosphamide treatment could be attributed to the higher serum level of antioxidants. © 2013 Blackwell Verlag GmbH.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: antioxidant; cyclophosphamide; ginger extract; malonaldehyde; protective agent; reactive oxygen metabolite; testosterone; alkylating agent; antioxidant; cyclophosphamide; malonaldehyde; plant extract; reactive oxygen metabolite; testosterone, adult; animal experiment; animal tissue; antioxidant activity; article; artificial diet; blood sampling; cell protection; comparative study; controlled study; decreased appetite; enzyme linked immunosorbent assay; germ cell; hair loss; histology; male; microscopy; nonhuman; randomized controlled trial; rat; seminiferous tubule; seminiferous tubule epithelium; Sertoli cell; single drug dose; spermatid; spermatocyte; spermatogonium; spermatozoon; testis; testis protection; testis weight; testosterone blood level; total antioxidant capacity; treatment duration; treatment outcome; animal; blood; drug effects; ginger; metabolism; pathology; spermatozoon count; testis; Wistar rat, Animals; Antineoplastic Agents, Alkylating; Antioxidants; Cyclophosphamide; Ginger; Male; Malondialdehyde; Plant Extracts; Rats; Rats, Wistar; Reactive Oxygen Species; Sertoli Cells; Sperm Count; Testis; Testosterone
Subjects: Anatomy Morphology
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Anatomy
Depositing User: editor . 2
Date Deposited: 05 Mar 2017 21:59
Last Modified: 11 Mar 2017 14:27
URI: http://eprints.kaums.ac.ir/id/eprint/456

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