Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems

Narmani, A. and Rezvani, M. and Farhood, B. and Darkhor, P. and Mohammadnejad, J. and Amini, B. and Refahi, S. and Abdi Goushbolagh, N. (2019) Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems. Drug Development Research, 80 (4). pp. 404-424.

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Conventional chemotherapeutic approaches in cancer therapy such as surgery, chemotherapy, and radiotherapy have several disadvantages due to their nontargeted distributions in the whole body. On the other hand, nanoparticles (NPs) based therapies are remarkably progressing to solve several limitations of conventional drug delivery systems (DDSs) including nonspecific biodistribution and targeting, poor water solubility, weak bioavailability and biodegradability, low pharmacokinetic properties, and so forth. The enhanced permeability and retention effect escape from P-glycoprotein trap in cancer cells as a passive targeting mechanism, and active targeting strategies are also other most important advantages of NPs in cancer diagnosis and therapy. Folic acid (FA) is one of the biologic molecules which has been targeted overexpressed-folic acid receptor (FR) on the surface of cancer cells. Therefore, conjugation of FA to NPs most easily enhances the FR-mediated targeting delivery of therapeutic agents. Here, the recent works in FA which have been decorated NPs-based DDSs are discussed and cancer therapy potency of these NPs in clinical trials are presented. © 2019 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 8
Uncontrolled Keywords: biopolymer; chitosan; dextran; folate receptor; folic acid; gold nanoparticle; graphene oxide; hyaluronic acid; nanocarrier; polyamidoamine; polyethyleneimine; polymer; ultrasmall superparamagnetic iron oxide, Article; cancer cell; cancer therapy; cell surface; clinical trial (topic); drug conjugation; drug delivery system; human; lipid bilayer; lipid monolayer; nonhuman
Subjects: Pharmacology, Toxicology and Pharmaceutics
Divisions: Faculty of Para medicine > Department of Management Radiology and Medical Physics
Depositing User: ART . editor
Date Deposited: 30 Dec 2019 11:56
Last Modified: 30 Dec 2019 11:56

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