Scolicidal Effects of Chitosan�Curcumin Nanoparticles on the Hydatid Cyst Protoscolices

Napooni, S. and Delavari, M. and Arbabi, M. and Barkheh, H. and Rasti, S. and Hooshyar, H. and Mostafa Hosseinpour Mashkani, S. (2019) Scolicidal Effects of Chitosan�Curcumin Nanoparticles on the Hydatid Cyst Protoscolices. Acta Parasitologica, 64 (2). pp. 367-375.

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Purpose: In the current era, cystic echinococcosis (CE), as larval stage of Echinococcus granulosus, is considered as a threat to human health. Scolicidal agents used in the surgery of cysts have different side effects. Therefore, the present study aimed to assess the effects of chitosan nanoparticles containing curcumin (Ch�Cu NPs) on the protoscolices of the hydatid cyst in vitro. Methods: Ch�Cu NPs were synthesized using a simple co-precipitation method and their structural and morphological properties were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta analyzer, and Fourier transform infrared (FT-IR) spectroscopy. Then, the effects of different concentrations of Ch�Cu NPs (0.25, 0.05, 1, 2, and 4 mg/mL) on the fatality rate, and the length and width of protoscolices in different times (5, 10, 20, 30, and 60 min) were investigated. In addition, the SEM technique was used to evaluate the structure of the protoscolices after treatment. Results: Based on the results, the presence of curcumin on the chitosan nanoparticles was confirmed by FT-IR analysis. Further, XRD analysis approved the crystal structure of chitosan NPs. Furthermore, the highest fatality rate was 68 in 4 mg/mL concentration of Ch�Cu NPs. The length and width of protoscolices decreased based on the high concentrations of Ch�Cu NPs, compared to the control group. Conclusion: Finally, Ch�Cu NPs expressed good scolicidal activities, which made them suitable to be considered as an anti-protoscolex agent. © 2019, Witold Stefa�ski Institute of Parasitology, Polish Academy of Sciences.

Item Type: Article
Additional Information: cited By 0
Subjects: Parasitology
Divisions: Faculty of Medicine > Basic Sciences > Department of Parasitological & Mycology
Depositing User: ART . editor
Date Deposited: 30 Dec 2019 14:28
Last Modified: 30 Dec 2019 14:28

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