Aghighi, F. and Mohammadifar, M. and Banafsheh, H. and Salami, M. and Talaei, S.A. (2019) Behavioral and electrophysiological aspects of cognition in neonate rats lactated by morphine addicted mothers. Iranian Journal of Basic Medical Sciences, 22 (9). pp. 1059-1064.
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Abstract
Objective(s): In addition to genetic factors, environmental phenomena during postnatal age highly affect development and, in turn, function of the brain. The present work evaluates if morphine consumption during lactation period influences the spatial performances and synaptic plasticity in rats at neonatal period of age. Materials and Methods: Three groups of mothers were subcutaneously administered by 5 (M5), 10 (M10) or 20 (M20) mg/kg morphine every 12 hours during the lactation period. At 45 days old, their offspring were introduced to Morris water maze for assessment of spatial learning and memory. Basic field excitatory post-synaptic potentials (fEPSPs) were recorded in the CA1 area of hippocampus and, then, long term potentiation (LTP) was induced by tetanic stimulation. Results: We found that the M10 and M20 rats spent more time and traveled longer distance to find the hidden platform of maze when compared to the control animals (P<0.05 for all comparisons). Similarly, these two morphine-exposed groups were inferior in the memory consolidation compared to their control counterparts. Comparing control and M20 rats revealed that morphine exposure decreases the mean amplitude and slope 10-90 of fEPSPs about 30 percent (P<0.001 for both comparisons) and inhibits the LTP induction in the CA1 area circuits. Conclusion: The present study provides behavioral and electrophysiological proofs for negative effect of morphine on the hippocampal-related function in the neonatally morphine-exposed rats. © 2019, Mashhad University of Medical Sciences. All rights reserved.
| Item Type: | Article |
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| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | morphine; naloxone, animal experiment; animal model; Article; basic field excitatory post synaptic potentials; behavioral addiction; cognition; controlled study; drug dose increase; drug exposure; drug withdrawal; electrophysiology; electrostimulation; Gellet Holtzman scale; hippocampal CA1 region; hippocampus; in vivo study; lactation; latent period; long term potentiation; male; memory consolidation; Morris water maze test; nonhuman; open field test; rat; scoring system; spatial learning; synapse; synaptic potential |
| Subjects: | Physiology Pharmacology, Toxicology and Pharmaceutics |
| Divisions: | Faculty of Medicine > Basic Sciences > Department of physiology |
| Depositing User: | ART . editor |
| Date Deposited: | 30 Dec 2019 12:57 |
| Last Modified: | 30 Dec 2019 12:57 |
| URI: | http://eprints.kaums.ac.ir/id/eprint/4539 |
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