The role of fibromodulin in cancer pathogenesis: Implications for diagnosis and therapy

Pourhanifeh, M.H. and Mohammadi, R. and Noruzi, S. and Hosseini, S.A. and Fanoudi, S. and Mohamadi, Y. and Hashemzehi, M. and Asemi, Z. and Mirzaei, H.R. and Salarinia, R. and Mirzaei, H. (2019) The role of fibromodulin in cancer pathogenesis: Implications for diagnosis and therapy. Cancer Cell International, 19 (1).

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Fibromodulin (FMOD) is known as one of very important extracellular matrix small leucine-rich proteoglycans. This small leucine-rich proteoglycan has critical roles in the extracellular matrix organization and necessary for repairing of tissue in many organs. Given that the major task of FMOD is the modulation of collagen fibrillogenesis. However, recently observed that FMOD plays very important roles in the modulation of a variety of pivotal biological processes including angiogenesis, regulation of TGF-β activity, and differentiation of human fibroblasts into pluripotent cells, inflammatory mechanisms, apoptosis and metastatic related phenotypes. Besides these roles, FMOD has been considered as a new tumor-related antigen in some malignancies such as lymphoma, leukemia, and leiomyoma. Taken together, these findings proposed that FMOD could be introduced as diagnostic and therapeutic biomarkers in treatment of various cancers. Herein, for first time, we highlighted the various roles of FMOD in the cancerous conditions. Moreover, we summarized the diagnostic and therapeutic applications of FMOD in cancer therapy. © 2019 The Author(s).

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: fibromodulin; integrin; transforming growth factor beta, apoptosis; cancer diagnosis; cancer growth; cancer prognosis; cancer therapy; carboxy terminal sequence; carcinogenesis; cell migration; disease association; epithelial mesenchymal transition; extracellular matrix; human; nonhuman; protein function; protein targeting; Review; tumor microenvironment; tumor vascularization
Subjects: Medicine
Divisions: Faculty of Medicine > Basic Sciences > Department of Pathology& Histology
Depositing User: ART . editor
Date Deposited: 31 Dec 2019 10:48
Last Modified: 31 Dec 2019 10:48

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