A comparison between the effects of flaxseed oil and fish oil supplementation on cardiovascular health in type 2 diabetic patients with coronary heart disease: A randomized, double-blinded, placebo-controlled trial

Raygan, F. and Taghizadeh, M. and Mirhosseini, N. and Akbari, E. and Bahmani, F. and Memarzadeh, M.R. and Sharifi, N. and Jafarnejad, S. and Banikazemi, Z. and Asemi, Z. (2019) A comparison between the effects of flaxseed oil and fish oil supplementation on cardiovascular health in type 2 diabetic patients with coronary heart disease: A randomized, double-blinded, placebo-controlled trial. Phytotherapy Research, 33 (7). pp. 1943-1951.

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Abstract

This study compared the effects of flaxseed and fish oil supplementation on cardiovascular risk parameters in diabetic patients with coronary heart disease. Participants were randomly allocated into three intervention groups to receive either 1,000 mg of omega-3 fatty acids from fish oil or 1,000 mg of omega-3 fatty acids from flaxseed oil or placebo (n = 30 each group) twice a day for 12 weeks. A significant reduction in insulin levels (.04) was observed following flaxseed oil and fish oil supplementation compared with the placebo. In addition, a significant reduction in high-sensitivity C-reactive protein (.02) was seen after flaxseed oil supplementation compared with the placebo and a significant increase in total nitrite (.001) was seen after flaxseed oil and fish oil intake compared with placebo. Additionally, a significant increase in total antioxidant capacity (p <.001) after consuming flaxseed oil and fish oil compared with placebo and glutathione levels (.001) after consuming fish oil compared with flaxseed oil and placebo was observed. Overall, our study revealed the beneficial effects of flaxseed oil and fish oil supplementation on few metabolic profiles. This study suggests that the effect of flaxseed oil in reducing insulin and increasing total nitrite and total antioxidant capacity is similar to fish oil. © 2019 John Wiley & Sons, Ltd.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: C reactive protein; fish oil; glutathione; high sensitivity C reactive protein; insulin; linseed oil; nitrite; omega 3 fatty acid; unclassified drug; fish oil; linseed oil; omega 3 fatty acid, adult; aged; antioxidant assay; Article; cardiovascular risk; comparative effectiveness; controlled study; diet supplementation; double blind procedure; female; follow up; human; insulin blood level; intervention study; ischemic heart disease; major clinical study; male; non insulin dependent diabetes mellitus; randomized controlled trial; comparative study; coronary artery disease; dietary supplement; middle aged; non insulin dependent diabetes mellitus; very elderly, Adult; Aged; Aged, 80 and over; Coronary Disease; Diabetes Mellitus, Type 2; Dietary Supplements; Double-Blind Method; Fatty Acids, Omega-3; Female; Fish Oils; Humans; Linseed Oil; Male; Middle Aged
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 31 Dec 2019 11:34
Last Modified: 31 Dec 2019 11:34
URI: http://eprints.kaums.ac.ir/id/eprint/4514

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