Mitigation of radiation-induced lung pneumonitis and fibrosis using metformin and melatonin: A histopathological study

Farhood, B. and Aliasgharzadeh, A. and Amini, P. and Rezaeyan, A. and Tavassoli, A. and Motevaseli, E. and Shabeeb, D. and Musa, A.E. and Najafi, M. (2019) Mitigation of radiation-induced lung pneumonitis and fibrosis using metformin and melatonin: A histopathological study. Medicina (Lithuania), 55 (8).

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Abstract

Background and objectives: Pneumonitis and fibrosis are the most common consequences of lung exposure to a high dose of ionizing radiation during an accidental radiological or nuclear event, and may lead to death, after some months to years. So far, some anti-inflammatory and antioxidant agents have been used for mitigation of lung injury. In the present study, we aimed to detect possible mitigatory effects of melatonin and metformin on radiation-induced pneumonitis and lung fibrosis. Materials and methods: 40 male mice were divided into 4 groups (10 mice in each). For control group, mice did not receive radiation or drugs. In group 2, mice were irradiated to chest area with 18 Gy gamma rays. In groups 3 and 4, mice were first irradiated similar to group 2. After 24 h, treatment with melatonin as well as metformin began. Mice were sacrificed after 100 days for determination of mitigation of lung pneumonitis and fibrosis by melatonin or metformin. Results: Results showed that both melatonin and metformin are able to mitigate pneumonitis and fibrosis markers such as infiltration of inflammatory cells, edema, vascular and alveolar thickening, as well as collagen deposition. Conclusion: Melatonin and metformin may have some interesting properties for mitigation of radiation pneumonitis and fibrosis after an accidental radiation event. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Item Type: Article
Additional Information: cited By 1
Subjects: Medicine
Pathology
Divisions: Faculty of Para medicine > Department of Management Radiology and Medical Physics
Depositing User: ART . editor
Date Deposited: 31 Dec 2019 12:02
Last Modified: 31 Dec 2019 12:02
URI: http://eprints.kaums.ac.ir/id/eprint/4490

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