Melatonin is an appropriate candidate for breast cancer treatment: Based on known molecular mechanisms

Amin, N. and Shafabakhsh, R. and Reiter, R.J. and Asemi, Z. (2019) Melatonin is an appropriate candidate for breast cancer treatment: Based on known molecular mechanisms. Journal of Cellular Biochemistry, 120 (8). pp. 12208-12215.

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Abstract

Breast cancer is the most prevalent cancer and one of the most important causes of death in women throughout the world. Breast cancer risk factors include smoking, alcohol consumption, personal and family history, hypertension, and hormone therapy, long-term use of nonsteroidal anti-inflammatory drugs and tobacco usage. Surgery, chemotherapy, radiotherapy, immunotherapy, and neoadjuvant therapy are the current means for breast cancer treatment. Despite hormonal agents and chemotherapy, which have beneficial effects on lowering breast cancer death rate, the reaction of different people to these treatments is still a challenging point. Melatonin (N-acetyl-5-methoxy tryptamine) is a methoxy indole compound that is mainly secreted by the pineal gland at night; it is as an antioxidant, anti-inflammatory, and oncostatic agent. On the basis of recent studies, melatonin has antitumor properties on different cancer types and it may suppress cancer development in vitro and as well as in animal models. It is suggested that melatonin inhibits the development of breast cancer by various mechanisms. This paper summarizes the roles of melatonin in breast cancer treatment from the aspect of its molecular actions. © 2019 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: melatonin, Article; breast cancer; breast carcinogenesis; cancer patient; human; inflammation; molecular pathology; oxidative stress; priority journal
Subjects: Medicine
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Biochemistry
Depositing User: ART . editor
Date Deposited: 31 Dec 2019 15:32
Last Modified: 31 Dec 2019 15:32
URI: http://eprints.kaums.ac.ir/id/eprint/4484

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