The effects of vitamin D treatment on glycemic control, serum lipid profiles, and C-reactive protein in patients with chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials

Milajerdi, A. and Ostadmohammadi, V. and Amirjani, S. and Kolahdooz, F. and Asemi, Z. (2019) The effects of vitamin D treatment on glycemic control, serum lipid profiles, and C-reactive protein in patients with chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials. International Urology and Nephrology, 51 (9). pp. 1567-1580.

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Abstract

Purpose: Insulin resistance, dyslipidemia and increased systemic inflammation are important risk factors for chronic kidney disease (CKD). Hence, vitamin D administration might be an appropriate approach to decrease the complications of CKD. Randomized controlled trials assessing the effects of vitamin D supplementation or treatment on glycemic control, lipid profiles, and C-reactive protein (CRP) among patients with CKD were included. Methods: Two independent authors systematically searched online databases including EMBASE, Scopus, PubMed, Cochrane Library, and Web of Science in November 2018 with no time restriction. Cochrane Collaboration risk of bias tool was applied to assess the methodological quality of included trials. Between-study heterogeneity was estimated using the Cochran�s Q test and I-square (I2) statistic. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size. Results: Of the 1358 citations identified from searches, 17 full-text articles were reviewed. Pooling findings from five studies revealed a significant reduction in fasting glucose (WMD: � 18.87; 95 CI: � 23.16, � 14.58) and in homeostatic model assessment of insulin resistance (HOMA-IR) through three studies (WMD: � 2.30; 95 CI: � 2.88, � 1.72) following the administration of vitamin D. In addition, pooled analysis revealed a significant reduction in triglycerides (WMD: � 32.52; 95 CI: � 57.57, � 7.47) through six studies and in cholesterol concentrations (WMD: � 7.93; 95 CI: � 13.03, � 2.83) through five studies, following vitamin D supplementation or treatment, while there was no effect on insulin, HbA1c, LDL and HDL cholesterol, and CRP levels. Conclusions: This meta-analysis demonstrated the beneficial effects of vitamin D supplementation or treatment on improving fasting glucose, HOMA-IR, triglycerides and cholesterol levels among patients with CKD, though it did not influence insulin, HbA1c, LDL and HDL cholesterol, and CRP levels. © 2019, Springer Nature B.V.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: C reactive protein; calcidiol; calcitriol; ergocalciferol; glucose; hemoglobin A1c; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; triacylglycerol; unclassified drug; vitamin D, cholesterol blood level; chronic kidney failure; effect size; glucose blood level; glycemic control; hemoglobin blood level; homeostasis model assessment; human; in vitro study; insulin blood level; protein blood level; randomized controlled trial (topic); Review; systematic review; triacylglycerol blood level; vitamin supplementation
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 01 Jan 2020 10:46
Last Modified: 01 Jan 2020 10:46
URI: http://eprints.kaums.ac.ir/id/eprint/4470

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