N-acetylcysteine in addiction management: Current knowledge and future perspectives

Ghaderi, A. and Vahed, N. and Ghayoomi, R. and Ostadmohammadi, V. and Gholami, M. and Dehkohneh, S. (2019) N-acetylcysteine in addiction management: Current knowledge and future perspectives. International Journal of Pharmaceutical Research, 11 (3). pp. 13-24.


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Drug abuse disorders and addictive behaviors are serious public health problems and major contributors to the global burden of disease. Previous studies show that N-acetylcysteine (NAC) may be involved in neurodevelopment adult brain. The potential neuroprotective effect of NACis associated with modulate several neurological pathways, including prevention of oxidative stress or inflammation damage to nervous tissue and glutamate dysregulation, NAC is being explored as an adjunctive therapy for drug addiction and addiction management.We here review the role of NAC in the addiction, such as cannabis abuse, methamphetamine abuse, cocaine addiction, nicotine dependency, and gambling.Adequate administrate of NAC seems to be crucial in terms of addiction management. NAC is safe and well tolerated when administered orally but has documented risks with intravenous administration. An evidence study supports its use as an adjunctive therapy clinically for drug addiction, administered concomitantly with existing medications. The aim of this review is to assess the current knowledge related to the role of NAC administration on drug addiction and addiction management. © 2019, Advanced Scientific Research. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: acetylcysteine; methamphetamine; neurotransmitter, addiction; antiinflammatory activity; Article; cannabis addiction; cocaine dependence; Diagnostic and Statistical Manual of Mental Disorders; drug abuse; drug bioavailability; drug dependence; drug exposure; drug mechanism; gambling; human; inflammation; oxidative stress; prevalence; psychologic assessment; smoking; substance abuse; tobacco dependence
Subjects: Pharmacology, Toxicology and Pharmaceutics
Divisions: Faculty of Medicine > Basic Sciences > Department of Pharmacology
Depositing User: ART . editor
Date Deposited: 01 Jan 2020 11:04
Last Modified: 01 Jan 2020 11:04
URI: http://eprints.kaums.ac.ir/id/eprint/4459

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