Electrochemical-based biosensors for microRNA detection: Nanotechnology comes into view

Shabaninejad, Z. and Yousefi, F. and Movahedpour, A. and Ghasemi, Y. and Dokanehiifard, S. and Rezaei, S. and Aryan, R. and Savardashtaki, A. and Mirzaei, H. (2019) Electrochemical-based biosensors for microRNA detection: Nanotechnology comes into view. Analytical Biochemistry, 581.

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Abstract

Nanotechnology plays an undeniable significant role in medical sciences, particularly in the field of biomedicine. Development of several diagnostic procedures in medicine has been possible through the beneficial application of nano-materials, among which electrochemical nano-biosensors can be mentioned. They can be employed to quantify various clinical biomarkers in detection, evaluation, and follow up stages of the illnesses. MicroRNAs, a group of regulatory short RNA fragments, added a new dimension to the management and diagnosis of several diseases. Mature miRNAs are single-stranded RNA molecules approximately 22 nucleotides in length, which regulate a vast range of biological functions from cellular proliferation and death to cancer development and progression. Recently, diagnostic value of miRNAs in various diseases has been demonstrated. There are many traditional methods for detection of miRNAs including northern blotting, quantitative real time PCR (qRT-PCR), microarray technology, nanotechnology-based approaches, and molecular biology tools including miRNA biosensors. In comparison with other techniques, electrochemical nucleic acid biosensor methods exhibit many interesting features, and could play an important role in the future nucleic acid analysis. This review paper provides an overview of some different types of nanotechnology-based biosensors for detection of miRNAs. © 2019

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: microRNA; microRNA 141; microRNA 155; microRNA 21, biogenesis; nanotechnology; priority journal; protein family; real time polymerase chain reaction; Review; RNA analysis
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Applied Cell Sciences
Depositing User: ART . editor
Date Deposited: 01 Jan 2020 11:26
Last Modified: 01 Jan 2020 11:26
URI: http://eprints.kaums.ac.ir/id/eprint/4446

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