Anti-cancer effects of cinnamon: Insights into its apoptosis effects

Sadeghi, S. and Davoodvandi, A. and Pourhanifeh, M.H. and Sharifi, N. and ArefNezhad, R. and Sahebnasagh, R. and Moghadam, S.A. and Sahebkar, A. and Mirzaei, H. (2019) Anti-cancer effects of cinnamon: Insights into its apoptosis effects. European Journal of Medicinal Chemistry, 178. pp. 131-140.


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Cancer is known as a leading cause of death worldwide. In the last two decades, the incidence of cancer has been dramatically increased mostly due to lifestyle changes. The importance of this issue has attracted further attention to discover novel therapies to prevent and treat cancers. According to previous studies, drugs used to treat cancer have shown significant limitations. Therefore, the role of herbal medicines alone or in combination with chemotherapy drugs has been extensively studied in cancer treatment. Cinnamon is a natural component showing a wide range of pharmacological functions including anti-oxidant, anti-microbial and anti-cancer activities. Impaired apoptosis plays critical roles in the initiation and progression of cancer. Increasing evidence indicates that cinnamon, as a therapeutic agent, has anti-cancer effects via affecting numerous apoptosis-related pathways in cancer cells. Here, we highlighted anticancer properties of cinnamon, particularly through targeting apoptosis-related mechanisms. © 2019 Elsevier Masson SAS

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: 2 methoxyestradiol; cinnamaldehyde; cinnamon extract; death receptor; essential oil; eugenol; gemcitabine; 2'-benzoyloxycinnamaldehyde; acrolein; antineoplastic agent; benzoic acid; eugenol; plant extract, antineoplastic activity; antioxidant activity; antiproliferative activity; apoptosis; cancer cell; cancer cell line; Cinnamomum zeylanicum; cinnamon; cytotoxicity; HeLa cell line; herbal medicine; human; IC50; in vitro study; in vivo study; malignant neoplasm; nonhuman; oncogenesis and malignant transformation; Review; signal transduction; analogs and derivatives; animal; apoptosis; chemistry; drug effect; tumor cell line, Acrolein; Animals; Antineoplastic Agents; Apoptosis; Benzoates; Cell Line, Tumor; Cinnamomum zeylanicum; Eugenol; Humans; Plant Extracts
Subjects: Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
Divisions: Faculty of Medicine > Basic Sciences > Department of Biochemistry
Depositing User: ART . editor
Date Deposited: 01 Jan 2020 11:21
Last Modified: 01 Jan 2020 11:21

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