Ghaderi, A. and Rasouli-Azad, M. and Vahed, N. and Banafshe, H.R. and Soleimani, A. and Omidi, A. and Ghoreishi, F.S. and Asemi, Z. (2019) Clinical and metabolic responses to crocin in patients under methadone maintenance treatment: A randomized clinical trial. Phytotherapy Research, 33 (10). pp. 2714-2725.
Full text not available from this repository.Abstract
Patients under methadone maintenance treatment (MMT) programs are susceptible to several complications including metabolic and clinical disorders. This study was designed to determine the effect of crocin supplementation on mental health parameters and metabolic profiles in subjects under MMT. The current randomized, double-blind, placebo-controlled, clinical trial was conducted among 53 patients under MMT to receive either 15 mg/day of crocin (n = 26) or placebo (n = 27) twice a day for 8 weeks. Crocin administration significantly decreased Beck Depression Inventory score (P = 0.01) and Beck Anxiety Inventory score (P = 0.008) compared with the placebo. In addition, crocin administration resulted in a significant reduction in fasting glucose (P = 0.003), insulin levels (P = 0.01), insulin resistance (P = 0.008), triglycerides (P = 0.001), very low-density lipoprotein (P = 0.001), total cholesterol levels (P = 0.03), and a significant increase in insulin sensitivity (.003) compared with the placebo. Additionally, crocin intake was associated with a significant reduction in high-sensitivity C-reactive protein (p <.001) and malondialdehyde (P = 0.001) and a significant rise in total antioxidant capacity levels (P = 0.01) compared with the placebo. The findings of this clinical trial indicate that taking crocin for 8 weeks by patients under MMT had beneficial effects on their mental health and improved their metabolic profiles. © 2019 John Wiley & Sons, Ltd.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 1 |
| Uncontrolled Keywords: | C reactive protein; cholesterol; crocin; glucose; insulin; malonaldehyde; methadone; placebo; triacylglycerol; very low density lipoprotein, adult; antioxidant activity; anxiety disorder; Article; Beck Anxiety Inventory; Beck Depression Inventory; cholesterol blood level; controlled study; depression; double blind procedure; drug efficacy; human; human cell; insulin resistance; insulin sensitivity; major clinical study; mental health; metabolic inhibition; methadone treatment; randomized controlled trial; scoring system; treatment response |
| Subjects: | Pharmacology, Toxicology and Pharmaceutics |
| Divisions: | Faculty of Medicine > Basic Sciences > Addiction Studies |
| Depositing User: | ART . editor |
| Date Deposited: | 01 Jan 2020 14:48 |
| Last Modified: | 01 Jan 2020 14:48 |
| URI: | http://eprints.kaums.ac.ir/id/eprint/4430 |
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