Electrochemical determination of the antipsychotic medication clozapine by a carbon paste electrode modified with a nanostructure prepared from titania nanoparticles and copper oxide

Ghanbari, M.H. and Shahdost-Fard, F. and Rostami, M. and Khoshroo, A. and Sobhani-Nasab, A. and Gholipour, N. and Salehzadeh, H. and Ganjali, M.R. and Rahimi-Nasrabadi, M. and Ahmadi, F. (2019) Electrochemical determination of the antipsychotic medication clozapine by a carbon paste electrode modified with a nanostructure prepared from titania nanoparticles and copper oxide. Microchimica Acta, 186 (11).

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Abstract

A nanostructure was prepared from titania nanoparticles and copper oxide (TiO2NP@CuO) and used to modify a carbon paste electrode (CPE). The modified CPE is shown to enable sensitive voltammetric determination of the drug clozapine (CLZ). The sensor was characterized by various techniques and some key parameters were optimized. Under the optimum conditions and at a working potential of 0.6 V (vs. Ag/AgCl), the modified CPE has two linear response ranges, one from 30 pmol L�1 to 4 nmol L�1 of CLZ, the other from 4 nmol L�1 to 10 μmol L�1. The detection limit is as low as 9 pM. The transfer coefficient (α) and catalytic rate constant (kcat) were calculated and the reliability of the sensor was estimated for CLZ sensing in real samples where it gave satisfactory results. Figure not available: see fulltext.. © 2019, Springer-Verlag GmbH Austria, part of Springer Nature.

Item Type: Article
Additional Information: cited By 0
Subjects: Chemistry
Pharmacology, Toxicology and Pharmaceutics
Divisions: Faculty of Medicine > Basic Sciences > Department of Pharmacology
Depositing User: ART . editor
Date Deposited: 01 Jan 2020 15:11
Last Modified: 01 Jan 2020 15:11
URI: http://eprints.kaums.ac.ir/id/eprint/4419

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