Selenium as an adjuvant for modification of radiation response

Farhood, B. and Mortezaee, K. and Motevaseli, E. and Mirtavoos-Mahyari, H. and Shabeeb, D. and Eleojo Musa, A. and Sanikhani, N.S. and Najafi, M. and Ahmadi, A. (2019) Selenium as an adjuvant for modification of radiation response. Journal of Cellular Biochemistry, 120 (11). pp. 18559-18571.

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DOI: UNSPECIFIED

Abstract

Ionizing radiation plays a central role in several medical and industrial purposes. In spite of the beneficial effects of ionizing radiation, there are some concerns related to accidental exposure that could pose a threat to the lives of exposed people. This issue is also very critical for triage of injured people in a possible terror event or nuclear disaster. The most common side effects of ionizing radiation are experienced in cancer patients who had undergone radiotherapy. For complete eradication of tumors, there is a need for high doses of ionizing radiation. However, these high doses lead to severe toxicities in adjacent organs. Management of normal tissue toxicity may be achieved via modulation of radiation responses in both normal and malignant cells. It has been suggested that treatment of patients with some adjuvant agents may be useful for amelioration of radiation toxicity or sensitization of tumor cells. However, there are always some concerns for possible severe toxicities and protection of tumor cells, which in turn affect radiotherapy outcomes. Selenium is a trace element in the body that has shown potent antioxidant and radioprotective effects for many years. Selenium can potently stimulate antioxidant defense of cells, especially via upregulation of glutathione (GSH) level and glutathione peroxidase activity. Some studies in recent years have shown that selenium is able to mitigate radiation toxicity when administered after exposure. These studies suggest that selenium may be a useful radiomitigator for an accidental radiation event. Molecular and cellular studies have revealed that selenium protects different normal cells against radiation, while it may sensitize tumor cells. These differential effects of selenium have also been revealed in some clinical studies. In the present study, we aimed to review the radiomitigative and radioprotective effects of selenium on normal cells/tissues, as well as its radiosensitive effect on cancer cells. © 2019 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: selenium derivative, adjuvant therapy; Article; cancer radiotherapy; drug effect; human; ionizing radiation; malignant neoplasm; nonhuman; priority journal; radiation exposure; radiation injury; radiation protection; radiation response; radiosensitivity; synergistic effect
Subjects: Medicine
Divisions: Faculty of Para medicine > Department of Management Radiology and Medical Physics
Depositing User: ART . editor
Date Deposited: 01 Jan 2020 14:59
Last Modified: 01 Jan 2020 14:59
URI: http://eprints.kaums.ac.ir/id/eprint/4413

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