The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: Basic science and new insights based on gene expression

Samimi, M. and Pourhanifeh, M.H. and Mehdizadehkashi, A. and Eftekhar, T. and Asemi, Z. (2019) The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: Basic science and new insights based on gene expression. Journal of Cellular Physiology, 234 (11). pp. 19384-19392.

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Abstract

Endometriosis is a frequent and chronic illness in young women which could be defined by the existence of endometrial stroma and glands outside of the normal site of the lining of the uterus. It has painful symptoms. The advanced stage of endometriosis may lead to gynecological malignancies, such as ovarian cancer, and other complications, including infertility. However, its exact physiopathology is not well known. Recent studies have shown the possible roles of inflammation along with oxidative stress. Additionally, angiogenesis and apoptosis dysregulation contribute to endometriosis pathophysiology. Therapeutic strategies and continuing attempts, to conquer endometriosis should be done regarding molecular signaling pathways. Thus, the present review summarizes current studies and focuses on molecular mechanisms. © 2019 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: heat shock protein; immunoglobulin enhancer binding protein, angiogenesis; apoptosis; cell death; endometriosis; female; gene expression; human; inflammation; oxidative stress; pathophysiology; priority journal; Review; signal transduction
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Applied Cell Sciences
Depositing User: ART . editor
Date Deposited: 01 Jan 2020 14:58
Last Modified: 01 Jan 2020 14:58
URI: http://eprints.kaums.ac.ir/id/eprint/4412

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