A meta-analysis of the prevalence of class 1 integron and correlation with antibiotic resistance in pseudomonas aeruginosa recovered from Iranian burn patients

Heidarzadeh, S. and Kaliji, Y.E. and Pourpaknia, R. and Mohammadzadeh, A. and Ghazali-Bina, M. and Saburi, E. and Vazini, H. and Khaledi, A. (2019) A meta-analysis of the prevalence of class 1 integron and correlation with antibiotic resistance in pseudomonas aeruginosa recovered from Iranian burn patients. Journal of Burn Care and Research, 40 (6). pp. 972-978.

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Abstract

The role of integrons has been highlighted in antibiotic resistance among Pseudomonas aeruginosa isolates. Therefore, we here reviewed the prevalence of class 1 integrons and their correlations with antibiotic resistance of P. aeruginosa isolated from Iranian burn patients. This review was conducted according to the guidelines of Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA). Cross-sectional and cohort studies published from January 1, 2000 until December 31, 2018 were enrolled. Meta-analysis was performed by Comprehensive Meta-Analysis (CMA) software using the random effects model, Cochran�s Q, and I2 tests. Publication bias was estimated by Funnel plot and Egger�s linear regression test. Nine out of 819 studies met the eligibility criteria. The overall combined prevalence of class 1 integrons in P. aeruginosa isolates was 69 (95 confidence interval CI: 50.5�83%). The highest combined resistance was reported against Cloxacillin (87.7%), followed by Carbenicillin (79.1%) and Ceftriaxone (77.3%). The combined prevalence of multidrug-resistant (MDR) isolates was 79.3% (95% CI: 31.1�97%). Also, a significant correlation was noted between the presence of class 1 integrons and antibiotic resistance in 55.5% of the included studies (P < .05). The results showed high prevalence of class 1 integrons, antibiotic resistance, and MDR strains in P. aeruginosa isolated from Iranian burn patients. Also, most of the included studies showed a significant correlation between the presence of class 1 integrons and antibiotic resistance. © American Burn Association 2019. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: amikacin; aztreonam; carbenicillin; cefepime; ceftriaxone; ciprofloxacin; cloxacillin; gentamicin; imipenem; piperacillin plus tazobactam; polymyxin B; ticarcillin; tobramycin, antibiotic resistance; Article; bacterium isolate; burn infection; burn patient; class 1 integron; cohort analysis; cross-sectional study; human; information retrieval; Iranian people; meta analysis (topic); multidrug resistance; prevalence; Pseudomonas aeruginosa
Subjects: Immunology and Microbiology
Divisions: Faculty of Medicine > Basic Sciences > Department of Microbiology & Immunology
Depositing User: ART . editor
Date Deposited: 01 Jan 2020 14:56
Last Modified: 01 Jan 2020 14:56
URI: http://eprints.kaums.ac.ir/id/eprint/4411

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