Association of A-197G polymorphism in interleukin-17 gene with chronic periodontitis: Evidence from six case-control studies with a computational biology approach

Farmohammadi, A. and Tavangar, A. and Ehteram, M. and Karimian, M. (2019) Association of A-197G polymorphism in interleukin-17 gene with chronic periodontitis: Evidence from six case-control studies with a computational biology approach. Journal of investigative and clinical dentistry, 10 (4). e12424.

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Abstract

AIM: The aim of the present study was to evaluate the association of interleukin-17 (IL-17) A-197G gene polymorphism with chronic periodontitis (CP) in a case-control study, a meta-analysis, and an in silico approach. METHODS: In the case-control study, 122 cases with CP and 126 healthy controls were recruited; IL-17 A-197G genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. In the meta-analysis, comprehensive literature retrieval was performed on valid databases to identify relevant studies. Bioinformatics tools were employed to investigate the effects of A-197G transition on the promoter region of IL-17. RESULTS: Our case-control study revealed a significant association between IL-17 A-197G transition and CP. The overall meta-analysis revealed significant associations between the IL-17 A-197G polymorphism and CP risk in homozygote co-dominant and recessive models. The stratified analysis also showed a statistically significant association between the mentioned transition and CP risk in the Caucasian population. The in silico analysis revealed that the A-197G polymorphism could make changes in protein-binding sites of the IL-17 promoter region. CONCLUSIONS: Our study supports that IL-17 A-197G transition could be a genetic risk factor for CP. However, further studies with a larger sample size among different ethnicities are required to obtain a more accurate conclusion. © 2019 John Wiley & Sons Australia, Ltd.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: interleukin 17, biology; case control study; chronic periodontitis; gene frequency; genetic predisposition; human; meta analysis; single nucleotide polymorphism, Case-Control Studies; Chronic Periodontitis; Computational Biology; Gene Frequency; Genetic Predisposition to Disease; Humans; Interleukin-17; Polymorphism, Single Nucleotide
Subjects: Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology
Divisions: Faculty of Medicine > Basic Sciences > Applied Cell Sciences
Depositing User: ART . editor
Date Deposited: 01 Jan 2020 14:54
Last Modified: 01 Jan 2020 14:54
URI: http://eprints.kaums.ac.ir/id/eprint/4410

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