Ghiasian, M. and Khamisabadi, F. and Kheiripour, N. and Karami, M. and Haddadi, R. and Ghaleiha, A. and Taghvaei, B. and Oliaie, S.S. and Salehi, M. and Samadi, P. and Ranjbar, A. (2019) Effects of crocin in reducing DNA damage, inflammation, and oxidative stress in multiple sclerosis patients: A double-blind, randomized, and placebo-controlled trial. Journal of Biochemical and Molecular Toxicology, 33 (12).
Full text not available from this repository.Abstract
Multiple sclerosis (MS) is an autoimmune disease in which the immune system attacks the nerve cells, resulting in neurological disorders. Oxidative stress, free radicals, and neuritis have important roles in MS pathogenesis. Here, we aim to evaluate the effect of crocin on inflammatory markers, oxidative damage, and deoxyribonucleic acid (DNA) damage in the blood of patients with MS. A total of 40 patients were divided into two groups, drug and placebo-treated groups, using random assignment. Participants of the intervention and control groups received two crocin capsules or placebo per day for 28 days, respectively. Findings revealed a significant decrease in the level of important pathogenic factors in MS, including lipid peroxidation, DNA damage, tumor necrosis factor-alpha, and interleukin 17 as well as a significant increase in the total antioxidant capacity in the serum of patients treated with crocin compared with the placebo group. Our results suggest the beneficial and therapeutic effects of crocin in MS. © 2019 Wiley Periodicals, Inc.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Subjects: | Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics |
| Divisions: | Faculty of Medicine > Basic Sciences > Department of Biochemistry |
| Depositing User: | ART . editor |
| Date Deposited: | 01 Jan 2020 15:23 |
| Last Modified: | 01 Jan 2020 15:23 |
| URI: | http://eprints.kaums.ac.ir/id/eprint/4403 |
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