The effect of saffron supplementation on blood glucose and lipid profile: A systematic review and meta-analysis of randomized controlled trials

Asbaghi, O. and Soltani, S. and Norouzi, N. and Milajerdi, A. and Choobkar, S. and Asemi, Z. (2019) The effect of saffron supplementation on blood glucose and lipid profile: A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine, 47.

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Abstract

Background: Despite several studies about the effects of saffron supplementation on serum concentrations of lipid and glucose profiles, no systematic study had summarized the findings. Therefore, we conduct current study to systematically summarize findings from studies about the effect of saffron supplementation on serum levels of glucose and lipid profiles and to do a meta-analysis, if possible. Methods: A systematic literature search was conducted for clinical trials published in PubMed, SCOPUS, EMBASE, Cochrane's Library and ISI Web of Science from the beginning to 22 February 2019. All randomized clinical trials on the effect of saffron supplementation on serum concentrations of lipid and glucose profiles were included. Results: In overall, six studies were included in the current study. Pooled analysis of six studies for the effect of saffron on serum TG, TC and FBG concentrations and of five studies for LDL and HDL, showed a significant reduction in TG (WMD: -8.93 mg/dl; 95 CI: -16.49 to -1.37, P = 0.02) and TC levels (WMD: -5.72 mg/dl; 95 CI: -11.10 to -0.34, P = 0.03), a significant increase in HDL levels (WMD: 2.7 mg/dl; 95 CI: 0.22 to 5.18, P = 0.03), and no significant effect on LDL (WMD: -2.30 mg/dl; 95 CI: -11.73 to 7.13, P = 0.63) and FBG levels (WMD: -5.30 mg/dl; 95 CI: -14.20 to 3.60, P = 0.51). Conclusion: We found a significant reduction in serum concentrations of TC and TG and a significant increase in serum levels of HDL following supplementation with saffron. Saffron supplementation had no significant influence on serum FPG and LDL concentrations. © 2019 Elsevier Ltd

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Crocus sativus extract; glucose; high density lipoprotein; low density lipoprotein; placebo; triacylglycerol, cholesterol blood level; coronary artery disease; glucose blood level; human; meta analysis; metabolic syndrome X; non insulin dependent diabetes mellitus; randomized controlled trial (topic); Review; schizophrenia; sexual dysfunction; systematic review
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Biochemistry
Depositing User: ART . editor
Date Deposited: 01 Jan 2020 15:21
Last Modified: 01 Jan 2020 15:21
URI: http://eprints.kaums.ac.ir/id/eprint/4402

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