Boosting immune system against cancer by melatonin: A mechanistic viewpoint

Mortezaee, K. and Potes, Y. and Mirtavoos-Mahyari, H. and Motevaseli, E. and Shabeeb, D. and Musa, A.E. and Najafi, M. and Farhood, B. (2019) Boosting immune system against cancer by melatonin: A mechanistic viewpoint. Life Sciences, 238.

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Cancer is a disease of high complexity. Resistance to therapy is a major challenge in cancer targeted therapies. Overcoming this resistance requires a deep knowledge of the cellular interactions within tumor. Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) are the main anti-cancer immune cells, while T regulatory cells (Tregs) and cancer associated fibroblasts (CAFs) facilitate immune escape of cancer cells. Melatonin is a natural agent with anti-cancer functions that has also been suggested as an adjuvant in combination with cancer therapy modalities such as chemotherapy, radiotherapy, immunotherapy and tumor vaccination. One of the main effects of melatonin is regulation of immune responses against cancer cells. Melatonin has been shown to potentiate the activities of anti-cancer immune cells, as well as attenuating the activities of Tregs and CAFs. It also has a potent effect on the mitochondria, which may change immune responses against cancer. In this review, we explain the mechanisms of immune regulation by melatonin involved in its anti-cancer effects. © 2019 Elsevier Inc.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: immunoglobulin enhancer binding protein; melatonin, antineoplastic activity; apoptosis; cancer adjuvant therapy; cancer immunization; cancer immunotherapy; cancer radiotherapy; cancer resistance; cancer stem cell; cytotoxic T lymphocyte; human; immune response; immune system; immunocompetent cell; immunoregulation; malignant neoplasm; mitochondrion; molecular mechanics; natural killer cell; nonhuman; regulatory T lymphocyte; Review; signal transduction; tumor microenvironment
Subjects: Physiology
Anatomy Morphology
Divisions: Faculty of Medicine > Basic Sciences > Department of physiology
Depositing User: ART . editor
Date Deposited: 04 Jan 2020 15:37
Last Modified: 04 Jan 2020 15:37

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