Mechanics insights of curcumin in myocardial ischemia: Where are we standing?

Ahmed, S. and Khan, H. and Mirzaei, H. (2019) Mechanics insights of curcumin in myocardial ischemia: Where are we standing? European Journal of Medicinal Chemistry, 183.


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Cardiovascular disorders are known as one of the main health problems which are associated with mortality worldwide. Myocardial ischemia (MI) is improper blood supply to myocardium which leads from serious complications to life-threatening problems like AMI, atherosclerosis, hypertension, cardiac-hypertrophy as well as diabetic associated complications as diabetic atherosclerosis/cardiomyopathy/hypertension. Despite several efforts, the current therapeutic platforms are not related with significant results. Hence, it seems, developing novel therapies are required. In this regard, increasing evidences indicated, curcumin (CRC) acts as cardioprotective agent. Given that CRC and its analogs exert their cardioprotective effects via affecting on a variety of cardiovascular diseases-related mechanisms (i.e., Inflammation, and oxidative stress). Herein, for first time, we have highlighted the protective impacts of CRC against MI. This review might be a steppingstone for further investigation into the clinical implications of the CRC against MI. Furthermore, it pulls in light of a legitimate concern for scientific community, seeking novel techniques and characteristic dynamic biopharmaceuticals for use against myocardial ischemia. © 2019 Elsevier Masson SAS

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: curcumin; lipid, acute heart infarction; antiarrhythmic activity; antihypertensive activity; apoptosis; atherogenesis; atherosclerosis; diabetic cardiomyopathy; heart muscle ischemia; heart ventricle hypertrophy; human; hypertension; inflammation; nonhuman; oxidative stress; Review
Subjects: Pharmacology, Toxicology and Pharmaceutics
Divisions: Faculty of Medicine > Basic Sciences > Department of Pharmacology
Depositing User: ART . editor
Date Deposited: 04 Jan 2020 15:32
Last Modified: 04 Jan 2020 15:32

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