The protective effects of curcumin on cytotoxic and teratogenic activity of retinoic acid in mouse embryonic liver

Barandeh, B. and Amini Mahabadi, J. and Azadbakht, M. and Gheibi Hayat, S.M. and Amini, A. (2019) The protective effects of curcumin on cytotoxic and teratogenic activity of retinoic acid in mouse embryonic liver. Journal of Cellular Biochemistry, 120 (12). pp. 19371-19376.

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Background: Retinoic acid (RA) is a synthetic vitamin derivative. It exerts toxic and teratogenic effects on the development of embryonic organs in dose- and time-dependent manners in mice. Curcumin is a compound obtained from rhizomes of turmeric (Curcuma longa) and has protective effects on teratogenic agents. The current study examined the effects of curcumin on embryos treated with RA. Methods: A total of 24 female NMRI mice (8-week-old pregnant mice) were investigated in the current study. All of them were treated for 10 days during days 15 to 50 of pregnancy. In the first group, the animals were fed with normal diets (control); in the second group, with 60 mg/kg all- trans RA; in the third group, with 10 mg/kg curcumin; and in the fourth group, with RA and curcumin in their diets. The animals were killed by cervical dislocation at the 18th day of pregnancy and embryos were separated from the uteruses. The embryo weight and crown rump (CR) length were measured, and the SPSS software was used to analyze data. Results: There was a significant increase in the lengths of CR and weights of embryos after using curcumin, but RA had no effect on the length of CR and weight of embryos at a dose of 60 mg/kg. Morphometric assay of liver tissue was performed, and data analysis indicated that there were significant differences between groups in terms of morphometric parameters of liver tissue. Therefore, RA increased the cell number and sinusoid diameter and decreased the cell areas in the embryonic liver tissue. However, curcumin decreased these side effects of RA on the embryonic liver tissue. Conclusion: The results indicated that curcumin could decrease the toxic and teratogenic effects of RA in mouse embryos. © 2019 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: curcumin; retinoic acid, animal cell; animal experiment; animal model; animal tissue; Article; cell count; controlled study; cytotoxicity; embryo; female; fetus weight; liver cell; liver tissue; liver toxicity; male; morphometry; mouse; nonhuman; pregnancy; priority journal; teratogenicity
Subjects: Anatomy Morphology
Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
Divisions: Faculty of Medicine > Basic Sciences > Department of Anatomy
Depositing User: ART . editor
Date Deposited: 04 Jan 2020 15:30
Last Modified: 04 Jan 2020 15:30

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