Effect of curcumin on diabetic peripheral neuropathic pain: Possible involvement of opioid system

Banafshe, H.R. and Hamidi, G.A. and Noureddini, M. and Mirhashemi, S.M. and Mokhtari, R. and Shoferpour, M. (2014) Effect of curcumin on diabetic peripheral neuropathic pain: Possible involvement of opioid system. European Journal of Pharmacology, 723 (1). pp. 202-206.

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Neuropathic pain is one of the most common complications of diabetes mellitus. As efficacy and tolerability of current therapy for neuropathic pain are not ideal, we need to develop the novel drug for better treatment. Curcumin as a natural flavonoid from Curcuma longa has considerable effects on nervous system such as, antidepressant, antinociceptive and neuroprotective effects. The present study was designed to investigate the effect of curcumin on diabetic peripheral neuropathic pain and possible involvement of opioid system. A single dose of 60 mg/kg streptozotocin was injected intraperitoneally to induce diabetes in rats. STZ-induced diabetic rats were treated with curcumin (50 mg/kg/day) acute and chronically. Thermal hyperalgesia and mechanical allodynia were measured on the days 0, 7, 14 and 21 after diabetes induction as behavioral scores of neuropathic pain. Chronic, but not acute, treatment with curcumin prevents the weight loss and attenuates mechanical allodynia in STZ-induced diabetic rats. Pretreatment with naloxone (1 mg/kg) significantly reduced anti-allodynic effect of chronic curcumin in von Frey filament test. Our results suggest that curcumin can be considered as a new therapeutic potential for the treatment of diabetic neuropathic pain and the activation of opioid system may be involved in the antinociceptive effect of curcumin. © 2013 Elsevier B.V.

Item Type: Article
Additional Information: cited By 18
Uncontrolled Keywords: Curcumin; Curcumin (PubChem CID: 969516); Diabetic peripheral neuropathic pain; Dimethyl sulphoxide (PubChem CID: 679); Mechanical allodynia; Naloxone (PubChem CID: 5464092); Rat; Streptozotocin; Streptozotocin (PubChem CID: 29327), Analgesics, Opioid; Animals; Behavior, Animal; Body Weight; Curcumin; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hyperalgesia; Male; Naloxone; Narcotic Antagonists; Neuralgia; Phytotherapy; Rats; Rats, Wistar
Subjects: Pharmacology, Toxicology and Pharmaceutics
Divisions: Faculty of Medicine > Basic Sciences > Department of Pharmacology
Depositing User: editor . 2
Date Deposited: 05 Mar 2017 22:23
Last Modified: 05 Mar 2017 22:23
URI: http://eprints.kaums.ac.ir/id/eprint/437

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