New trends in glioma cancer therapy: Targeting Na+/H + exchangers

Tamtaji, O.R. and Mirzaei, H. and Shamshirian, A. and Shamshirian, D. and Behnam, M. and Asemi, Z. (2020) New trends in glioma cancer therapy: Targeting Na+/H + exchangers. Journal of Cellular Physiology, 235 (2). pp. 658-665.

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DOI: UNSPECIFIED

Abstract

Glioma is the oneof the most prevalent primarybrain tumors. There is a variety of oxidative stresses, inflammatory pathways, apoptosis signaling, and Na+/H + exchangers (NHEs) involved in the pathophysiology of glioma. Previous studies have indicated a relationship between NHEs and some molecular pathways in glioma. NHEs, including NHE1, NHE5, and NHE9 affect apoptosis, tumor-associated macrophage inflammatory pathways, matrix metalloproteinases, cancer-cell growth, invasion, and migration of glioma. Also, inhibition of NHEs contributes to increased survival in animal models of glioma. Limited studies, however, have assessed the relationship between NHEs and molecular pathways in glioma. This review summarizes current knowledge and evidence regarding the relationship between NHEs and glioma, and the mechanisms involved. © 2019 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: matrix metalloproteinase; nhe5 protein; nhe9 protein; sodium proton exchange protein; sodium proton exchange protein 1; tumor protein; unclassified drug, apoptosis; cancer growth; cancer therapy; cell migration; cell proliferation; cell survival; glioma; human; inflammation; pathophysiology; priority journal; Review; trend study; tumor associated leukocyte; tumor invasion
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Biochemistry
Depositing User: ART . editor
Date Deposited: 05 Jan 2020 12:50
Last Modified: 05 Jan 2020 12:50
URI: http://eprints.kaums.ac.ir/id/eprint/4364

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