Surveillance, control and management of infections in intensive care units in Southern Europe, Turkey and Iran - A prospective multicenter point prevalence study

Erdem, H. and Inan, A. and Altindis, S. and Carevic, B. and Askarian, M. and Cottle, L. and Beovic, B. and Csomos, A. and Metodiev, K. and Ahmetagic, S. and Harxhi, A. and Raka, L. and Grozdanovski, K. and Nechifor, M. and Alp, E. and Bozkurt, F. and Hosoglu, S. and Balik, I. and Yilmaz, G. and Jereb, M. and Moradi, F. and Petrov, N. and Kaya, S. and Koksal, I. and Aslan, T. and Elaldi, N. and Akkoyunlu, Y. and Moravveji, S.A. and Csato, G. and Szedlak, B. and Akata, F. and Oncu, S. and Grgic, S. and Cosic, G. and Stefanov, C. and Farrokhnia, M. and MÃller, M. and Luca, C. and Koluder, N. and Korten, V. and Platikanov, V. and Ivanova, P. and Soltanipour, S. and Vakili, M. and Farahangiz, S. and Afkhamzadeh, A. and Beeching, N. and Ahmed, S.S. and Cami, A. and Shiraly, R. and Jazbec, A. and Mirkovic, T. and Leblebicioglu, H. and Naber, K. (2014) Surveillance, control and management of infections in intensive care units in Southern Europe, Turkey and Iran - A prospective multicenter point prevalence study. Journal of Infection, 68 (2). pp. 131-140.

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Objective: We aimed to compare the features of intensive care units (ICUs), their antimicrobial resistance patterns, infection control policies, and distribution of infectious diseases from central Europe to Mid-West Asia. Methods: A cross-sectional point prevalence study was performed in 88 ICUs from 12 countries. Characteristics of ICUs, patient and antibiotic therapy data were collected with a standard form by infectious diseases specialists. Results: Out of 749, 305 patients at least with one infectious disease were assessed and 254 patients were reported to have coexistent medical problems. When primary infectious diseases diagnoses of the patients were evaluated, 69 had community-acquired, 61 had healthcare-associated, and 176 had hospital-acquired infections. Pneumonia was the most frequent ICU infection seen in half of the patients. Distribution of frequent pathogens was as follows: Enteric Gram-negatives ( n=62, 28.8), Acinetobacter spp. ( n=47, 21.9), Pseudomonas aeruginosa ( n=29, 13.5). Multidrug resistance profiles of the infecting microorganisms seem to have a uniform pattern throughout Southern Europe and Turkey. On the other hand, active and device-associated infection surveillance was performed in Turkey more than Iran and Southeastern Europe ( p<0.05). However, designing antibiotic treatment according to culture results was highest in Southeastern Europe ( p<0.05). The most frequently used antibiotics were carbapenems ( n=92, 30.2), followed by anti-gram positive agents (vancomycin, teicoplanin, linezolid, daptomycin, and tigecycline; n=79, 25.9), beta-lactam/beta lactamase inhibitors ( n=78, 25.6), and extended-spectrum cephalosporins ( n=73, 23.9). Conclusion: ICU features appears to have similar characteristics from the infectious diseases perspective, although variability seems to exist in this large geographical area. © 2013 The British Infection Association.

Item Type: Article
Additional Information: cited By 13
Uncontrolled Keywords: aminoglycoside antibiotic agent; beta lactam antibiotic; beta lactamase inhibitor; carbapenem derivative; cephalosporin derivative; ciprofloxacin; colistin; daptomycin; linezolid; metronidazole; ornidazole; quinoline derived antiinfective agent; teicoplanin; tigecycline; vancomycin, Acinetobacter; adult; antibiotic resistance; antibiotic therapy; article; clinical feature; community acquired infection; community acquired pneumonia; comorbidity; comparative study; controlled study; cross-sectional study; device infection; disease severity; disease surveillance; female; geographic distribution; Gram negative bacterium; health care policy; hospital infection; human; infection; infection control; infection prevention; intensive care unit; Iran; length of stay; major clinical study; male; multidrug resistance; prevalence; primary infection; prospective study; Pseudomonas aeruginosa; quality control; Southern Europe; treatment duration; Turkey (republic), Europe; ICU; Infection; Iran; Resistance; Turkey, Adult; Aged; Communicable Diseases; Cross Infection; Cross-Sectional Studies; Europe; Female; Humans; Intensive Care Units; Iran; Male; Middle Aged; Prevalence; Prospective Studies; Turkey
Subjects: Medicine
Divisions: Faculty of Medicine > Basic Sciences > Department of Science General
Depositing User: editor . 2
Date Deposited: 05 Mar 2017 22:06
Last Modified: 05 Mar 2017 22:06

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