Effects of Chromium and Carnitine Co-supplementation on Body Weight and Metabolic Profiles in Overweight and Obese Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial

Jamilian, M. and Foroozanfard, F. and Kavossian, E. and Kia, M. and Aghadavod, E. and Amirani, E. and Asemi, Z. (2019) Effects of Chromium and Carnitine Co-supplementation on Body Weight and Metabolic Profiles in Overweight and Obese Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial. Biological Trace Element Research.

[img] Text
Jamilian2019_Article_EffectsOfChromiumAndCarnitineC.pdf

Download (340kB)
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....
DOI: UNSPECIFIED

Abstract

The primary aim of our study was to determine the influence of taking chromium plus carnitine on insulin resistance, with a secondary objective of evaluating the influences on lipid profiles and weight loss in overweight subjects with polycystic ovary syndrome (PCOS). In a 12-week randomized, double-blind, placebo-controlled clinical trial, 54 overweight women were randomly assigned to receive either supplements (200 μg/day chromium picolinate plus 1000 mg/day carnitine) or placebo (27/each group). Chromium and carnitine co-supplementation decreased weight (� 3.6 ± 1.8 vs. � 1.0 ± 0.7 kg, P < 0.001), BMI (� 1.3 ± 0.7 vs. � 0.3 ± 0.3 kg/m 2 , P < 0.001), fasting plasma glucose (FPG) (� 5.1 ± 6.0 vs. � 1.1 ± 4.9 mg/dL, P = 0.01), insulin (� 2.0 ± 1.4 vs. � 0.2 ± 1.2 μIU/mL, P < 0.001), insulin resistance (� 0.5 ± 0.4 vs. � 0.04 ± 0.3, P < 0.001), triglycerides (� 18.0 ± 25.2 vs. + 5.5 ± 14.4 mg/dL, P < 0.001), total (� 17.0 ± 20.3 vs. + 3.6 ± 12.0 mg/dL, P < 0.001), and LDL cholesterol (� 13.3 ± 19.2 vs. + 1.4 ± 13.3 mg/dL, P = 0.002), and elevated insulin sensitivity (+ 0.007 ± 0.005 vs. + 0.002 ± 0.005, P < 0.001). In addition, co-supplementation upregulated peroxisome proliferator-activated receptor gamma (P = 0.02) and low-density lipoprotein receptor expression (P = 0.02). Overall, chromium and carnitine co-supplementation for 12 weeks to overweight women with PCOS had beneficial effects on body weight, glycemic control, lipid profiles except HDL cholesterol levels, and gene expression of PPAR-γ and LDLR. Clinical trial registration number: http://www.irct.ir: IRCT20170513033941N38. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

Item Type: Article
Additional Information: cited By 0
Subjects: Nutrition
Endocrinology Metabolism
Midwifery
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 13 Jul 2019 09:11
Last Modified: 13 Jul 2019 09:11
URI: http://eprints.kaums.ac.ir/id/eprint/4282

Actions (login required)

View Item View Item