Current approaches of the management of mercury poisoning: Need of the hour

Rafati-Rahimzadeh, M. and Rafati-Rahimzadeh, M. and Kazemi, S. and Moghadamnia, A.A. (2014) Current approaches of the management of mercury poisoning: Need of the hour. DARU, Journal of Pharmaceutical Sciences, 22 (1).

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DOI: UNSPECIFIED

Abstract

Mercury poisoning cases have been reported in many parts of the world, resulting in many deaths every year. Mercury compounds are classified in different chemical types such as elemental, inorganic and organic forms. Long term exposure to mercury compounds from different sources e.g. water, food, soil and air lead to toxic effects on cardiovascular, pulmonary, urinary, gastrointestinal, neurological systems and skin. Mercury level can be measured in plasma, urine, feces and hair samples. Urinary concentration is a good indicator of poisoning of elemental and inorganic mercury, but organic mercury (e.g. methyl mercury) can be detected easily in feces. Gold nanoparticles (AuNPs) are a rapid, cheap and sensitive method for detection of thymine bound mercuric ions. Silver nanoparticles are used as a sensitive detector of low concentration Hg2+ ions in homogeneous aqueous solutions. Besides supportive therapy, British anti lewisite, dimercaprol (BAL), 2,3-dimercaptosuccinic acid (DMSA. succimer) and dimercaptopropanesulfoxid acid (DMPS) are currently used as chelating agents in mercury poisoning. Natural biologic scavengers such as algae, azolla and other aquatic plants possess the ability to uptake mercury traces from the environment. © 2014 Rafati-Rahimzadeh et al.; licensee BioMed Central Ltd.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: activated carbon; chelating agent; dimercaprol; dimercaptopropanesulfoxid acid; elemental mercury; gold nanoparticle; inorganic mercury; mercury; methylmercury; organomercury compound; penicillamine; silver nanoparticle; succimer; thymine; unclassified drug; unithiol; water, air; alga; aquatic species; aqueous solution; article; artificial ventilation; azolla; cardiovascular system; endotracheal intubation; feces level; fern; food; gastrointestinal tract; hair level; hemodialysis; human; kidney concentrating capacity; long term exposure; mercurialism; nail; nanofiltration; nanomedicine; nervous system; neurologic disease; oxygen therapy; plasmapheresis; respiratory system; skin; soil; tracheobronchial toilet; urinary tract; urine level
Subjects: Health Professions
Divisions: Faculty of Para medicine > Department of Management Radiology and Medical Physics
Depositing User: editor . 2
Date Deposited: 06 Mar 2017 16:24
Last Modified: 06 Mar 2017 16:24
URI: http://eprints.kaums.ac.ir/id/eprint/414

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