The effects of probiotic and synbiotic supplementation on inflammatory markers among patients with diabetes: A systematic review and meta-analysis of randomized controlled trials

Tabrizi, R. and Ostadmohammadi, V. and Lankarani, K.B. and Akbari, M. and Akbari, H. and Vakili, S. and Shokrpour, M. and Kolahdooz, F. and Rouhi, V. and Asemi, Z. (2019) The effects of probiotic and synbiotic supplementation on inflammatory markers among patients with diabetes: A systematic review and meta-analysis of randomized controlled trials. European Journal of Pharmacology. pp. 254-264.

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Abstract

This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to evaluate the effect of probiotic and symbiotic supplementation on inflammatory markers among patients with diabetes. Clinical trials were searched using Cochrane Library, EMBASE, PubMed, and Web of Science online databases for relevant trials published until April 2018. Two independent investigators evaluated study eligibility, extracted data, and assessed risk of bias of included clinical trials. Cochran's Q test and I-square (I 2 ) statistic were used to detect heterogeneity among the included. Data were pooled by using the random-effect model and standardized mean difference (SMD) was considered as the summary effect size. From 986 originally identified publications 18 clinical trials with a total of 1337 patients were included. Findings showed that probiotic and synbiotic supplementation among patients with diabetes significantly decreased tumor necrosis factor-α (TNF-α) (SMD = �2.99; 95 CI, �4.77, �1.20; P = 0.001; I 2 : 96.3), and C-reactive protein (CRP) (SMD = �0.87; 95 CI, �1.27, �0.48; P < 0.001; I 2 : 90.2); while significantly increased nitric oxide (NO) concentrations (SMD = 1.49; 95 CI, 0.81, 2.16; P < 0.001; I 2 : 92.1). There were no effects of probiotic and synbiotic supplementation on interleukin-6 (IL-6) levels (SMD = �0.65; 95 CI, �1.88, 0.59; P = 0.30; I 2 : 94.7). In summary, the current meta-analysis demonstrated probiotic and synbiotic supplementation among patients with diabetes significantly decreased CRP and TNF-α, and increased NO levels, but did not affect IL-6 levels. © 2019

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: C reactive protein; interleukin 6; nitric oxide; probiotic agent; synbiotic agent; tumor necrosis factor, clinical outcome; concentration (parameter); diabetes mellitus; diabetic patient; drug effect; human; meta analysis; priority journal; randomized controlled trial (topic); Review; risk assessment; sensitivity analysis; supplementation; systematic review
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 24 Aug 2019 12:21
Last Modified: 24 Aug 2019 12:21
URI: http://eprints.kaums.ac.ir/id/eprint/4137

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