Protective effect of cerium oxide nanoparticle on sperm quality and oxidative damage in malathioninduced testicular toxicity in rats: An experimental study

Moridi, H. and Hosseini, S.A. and Shateri, H. and Kheiripour, N. and Kaki, A. and Hatami, M. and Ranjbar, A. (2018) Protective effect of cerium oxide nanoparticle on sperm quality and oxidative damage in malathioninduced testicular toxicity in rats: An experimental study. International Journal of Reproductive BioMedicine, 16 (4). pp. 261-266.

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Abstract

Background: Malathion is an organophosphorus pesticide that commonly used in many agricultural and non-agricultural processes. Previous studies have reported the effects of melatonin on the reproductive system. Cerium dioxide nanoparticles (CeNPs) due to their antioxidative properties are promising to impact on the development of male infertility. Objective: The aim of this study was to evaluate the effect of CeNPs on oxidative stress and sperm parameters after malathion exposure of male rats. Materials and Methods: 36 adult male Wistar rats were divided into 6 groups (n=6/each): Control, CeNPs -treated control (15 and 30 mg/kg/day), malathion (100 mg/ kg/day), and CeNPs -treated malathion groups (15 and 30 mg/ kg/day). At the end of the study (4 wk), the sperm counts, motility, and viability in the testis of rats were measured, also lipid peroxidation, total antioxidant capacity, and total thiol groups in homogenate testis were investigated. Results: Malathion significantly reduced sperm count, viability, and motility than the control rats (p<0.001). Co-treatment of malathion with CeNPs 30 mg/kg had a protective effect on sperm counts (p=0.03), motility (p=0.01), and viability (p<0.001) compare to malathion group. Also, the results showed that malathion reduced testis total anti-oxidant capacity, the total thiol group, and increased testis malondialdehyde than the control rats (p<0.001). CeNPs 30 mg/kg are increased total antioxidant capacity (p<0.001) and total thiol group (p=0.03) compared to malathion group. CeNPs at both doses (15 and 30 mg/kg) improved malondialdehyde than the malathion group (p<0.001 and p=0.01 respectively). Conclusion: CeNPs 30 mg/kg administered considerably restored testicular changes induced by malathion. The improvement of oxidative stress by CeNPs may be associated with increased sperm counts, motility and viability in the testis. © 2018, Research and Clinical Center for Infertitlity. All rights reserved.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: 5,5' dithiobis(2 nitrobenzoic acid); antioxidant; cerium oxide nanoparticle; edetic acid; malathion; malonaldehyde; protective agent; thiobarbituric acid; thiol group, adult; animal experiment; animal model; animal tissue; antioxidant activity; antioxidant assay; Article; cell viability; controlled study; lipid peroxidation; male; male infertility; nonhuman; oxidative stress; rat; reproductive toxicity; semen analysis; sperm quality; spermatozoon count; spermatozoon motility; testis
Subjects: Anatomy Morphology
Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
Divisions: Faculty of Medicine > Basic Sciences > Applied Cell Sciences
Depositing User: ART . editor
Date Deposited: 10 Apr 2019 12:03
Last Modified: 10 Apr 2019 12:03
URI: http://eprints.kaums.ac.ir/id/eprint/4081

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