Clinical Trial on the Effects of Vitamin D Supplementation on Metabolic Profiles in Diabetic Hemodialysis

Tamadon, M.R. and Soleimani, A. and Keneshlou, F. and Mojarrad, M.Z. and Bahmani, F. and Naseri, A. and Kashani, H.H. and Hosseini, E.S. and Asemi, Z. (2018) Clinical Trial on the Effects of Vitamin D Supplementation on Metabolic Profiles in Diabetic Hemodialysis. Hormone and Metabolic Research, 50 (1). pp. 50-55.

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The current study was conducted to assess the effects of vitamin D supplementation on insulin metabolism, lipid fractions, biomarkers of inflammation, and oxidative stress in diabetic hemodialysis (HD) patients. This randomized double-blind placebo-controlled clinical trial was carried out among 60 diabetic HD patients. Subjects were randomly allocated into two groups to intake either oral vitamin D3 supplements at a dosage of 50 000 IU (n=30) or placebo (n=30) every 2 weeks for 12 weeks. After 12 weeks of intervention, subjects who received vitamin D supplements compared with the placebo had significantly decreased serum insulin concentrations (-3.4±3.7 vs. +2.0±4.2 μIU/ml, p<0.001), homeostasis model of assessment-estimated insulin resistance (HOMA-IR) (-1.2±1.8 vs. +0.9±2.3, p<0.001), and improved quantitative insulin sensitivity check index (QUICKI) (+0.02±0.03 vs. -0.01±0.02, p<0.001). In addition, compared with the placebo, vitamin D supplementation led to significant reductions in serum high-sensitivity C-reactive protein (hs-CRP) (-1.4±2.5 vs. +1.4±4.8 mg/l, p=0.007), plasma malondialdehyde (MDA) (-0.1±0.2 vs. +0.1±0.2 μmol/l, p=0.009) and a significant increase in plasma total antioxidant capacity (TAC) concentrations (+33.8±56.7 vs. -2.0±74.5 mmol/l, p=0.04). We did not see any significant effect of vitamin D supplementation on lipid profiles and other biomarkers of inflammation and oxidative stress compared with the placebo. Overall, we found that vitamin D supplementation had beneficial effects on serum insulin, HOMA-IR, QUICKI, serum hs-CRP, plasma MDA, and TAC levels among diabetic HD patients for 12 weeks. Clinical registration: IRCT201611155623N92. © Georg Thieme Verlag KG Stuttgart.New York.

Item Type: Article
Additional Information: cited By 7
Uncontrolled Keywords: antioxidant; biological marker; C reactive protein; colecalciferol; insulin; lipid; malonaldehyde; placebo; vitamin D, adult; antioxidant assay; Article; controlled study; diabetes mellitus; diabetic patient; double blind procedure; drug efficacy; glycemic control; hemodialysis; homeostasis model assessment; human; inflammation; insulin blood level; insulin metabolism; insulin resistance; lipid analysis; lipid blood level; major clinical study; oxidative stress; plasma; priority journal; protein blood level; Quantitative Insulin Sensitivity Check Index; randomized controlled trial; risk reduction; total antioxidant capacity; vitamin supplementation; diabetes mellitus; dietary supplement; female; male; metabolism, Diabetes Mellitus; Dietary Supplements; Female; Humans; Male; Renal Dialysis; Vitamin D
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 13 Apr 2019 09:51
Last Modified: 13 Apr 2019 09:51

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