The effects of expression of different microRNAs on insulin secretion and diabetic nephropathy progression

Mafi, A. and Aghadavod, E. and Mirhosseini, N. and Mobini, M. and Asemi, Z. (2018) The effects of expression of different microRNAs on insulin secretion and diabetic nephropathy progression. Journal of Cellular Physiology, 234 (1). pp. 42-50.

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Abstract

MicroRNAs (miRNAs) have recently become well-known efficacious biomarkers for the diagnosis of diabetic nephropathy (DN). MiRNAs, short noncoding RNAs, are posttranscriptional regulators of gene expression, which regulate several biological cell functions, including insulin production and secretion, as well as insulin resistance in tissues. Today, the focus of the medical world is centered on the role of miRNAs as mediators for different diseases, such as DN and end-stage renal diseases (ESRD). MiRNAs are stable and detectable in human biological fluids, so their detection for early diagnosis of different diseases is highly sensitive and specific. Previous reports have shown that the alteration of miRNA profiles significantly correlates with specific stages of DN, kidney fibrosis, and renal dysfunction. This review was aimed at assessing the pathway of different miRNA expressions responsible for insulin secretion disorder and DN progression. © 2018 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: biological marker; insulin; microRNA; oligonucleotide, adipocyte; adipose tissue; biogenesis; body fluid; clinical practice; diabetic nephropathy; disease exacerbation; early diagnosis; end stage renal disease; gene expression; gene therapy; human; insulin release; insulin resistance; kidney fibrosis; kidney tissue; liver tissue; mediator release; muscle tissue; nonhuman; priority journal; Review; sensitivity and specificity
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Biochemistry
Depositing User: ART . editor
Date Deposited: 13 Apr 2019 09:17
Last Modified: 13 Apr 2019 09:17
URI: http://eprints.kaums.ac.ir/id/eprint/4063

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