Antinociceptive effects of venlafaxine in a rat model of peripheral neuropathy: Role of alpha2-adrenergic receptors

Hajhashemi, V. and Banafshe, H.R. and Minaiyan, M. and Mesdaghinia, A. and Abed, A. (2014) Antinociceptive effects of venlafaxine in a rat model of peripheral neuropathy: Role of alpha2-adrenergic receptors. European Journal of Pharmacology, 738. pp. 230-236.

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This study was designed to determine whether acute or chronic venlafaxine administration was effective in alleviating symptoms of neuropathic pain in a rat model of neuropathic pain, and whether the effect of venlafaxine involved manipulation of α2-adrenoceptors,by determining the effect of yohimbine, a α2-adrenoceptor antagonist on its actions. Neuropathic pain was induced by chronic constriction injury (CCI) of the sciatic nerve in the rats that resulted in stimulus-evoked thermal hyperalgesia, tactile mechanical and cold allodynia. Acute venlafaxine injections (20 and 40 mg/kg i.p.) on the 7th, 14th and 21st postoperative days could not reduce tactile and cold hypersensitivity significantly compared to CCI group. But in these groups venlafaxine (40 mg/kg i.p.) blocked heat hyperalgesia. When venlafaxine (10 and 20 mg/kg i.p.) administration was started on the first day after CCI and given daily until the 14th day, tactile hypersensitivity and heat hyperalgesia considerably were attenuated. But when venlafaxine (20 mg/kg i.p.) treatment was initiated on the 10th day after CCI, once the model had been fully established, and given daily for 11 days, no differences in withdrawal thresholds were observed compared with CCI group however heat hyperalgesia significantly has been blocked. Also the effect of venlafaxine on heat hyperalgesia was reversed by pretreatment with yohimbine at all-time intervals. These results indicate that venlafaxine, when administered immediately after nerve injury, and for a sufficient period of time, can prevent the development and expression of neuropathic pain. Also we conclude that α2- adrenoceptors participate in the antinociceptive effects of venlafaxine. © 2014 Elsevier B.V.

Item Type: Article
Additional Information: cited By 6
Uncontrolled Keywords: alpha 2 adrenergic receptor; venlafaxine; yohimbine; alpha 2 adrenergic receptor; alpha 2 adrenergic receptor blocking agent; analgesic agent; cyclohexanol derivative; venlafaxine; yohimbine, allodynia; analgesic activity; analysis of variance; animal experiment; animal model; antinociception; article; cold sensitivity; controlled study; drug antagonism; drug efficacy; drug safety; hyperalgesia; male; neuropathic pain; nonhuman; pain threshold; peripheral neuropathy; priority journal; protein analysis; protein function; rat; sciatic nerve injury; animal; animal behavior; drug effects; hyperalgesia; metabolism; neuralgia; Sprague Dawley rat, Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Behavior, Animal; Cyclohexanols; Hyperalgesia; Male; Neuralgia; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Yohimbine
Subjects: Pharmacology, Toxicology and Pharmaceutics
Divisions: Faculty of Medicine > Basic Sciences > Department of Pharmacology
Depositing User: editor . 2
Date Deposited: 06 Mar 2017 16:27
Last Modified: 06 Mar 2017 16:27

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