Nasal carriage and resistance pattern of multidrug resistant staphylococcus aureus among healthy children in kashan, Iran

Erami, M. and Soltani, B. and Taghavi-Ardakani, A. and Moravveji, S.A. and Haji Rezaei, M. and Soltani, S. and Moniri, R. (2014) Nasal carriage and resistance pattern of multidrug resistant staphylococcus aureus among healthy children in kashan, Iran. Iranian Red Crescent Medical Journal, 16 (9).

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Abstract

Background: Nasal carriage of Staphylococcus aureus is a substantial source of human infections. Detection and treatment of nasal carriage in children with methicillin-resistant and multidrug resistant S. aureus (MRSA and MDRSA, respectively) may be an important modality in prevention of infections. Objectives: This study determined the prevalence, antibiotic resistance patterns and risk factors for nasal carriage of MDRSA among healthy children. Patients and Methods: This cross-sectional study was carried out on 350 one-month to 14-year-old healthy children in Kashan city, Iran. From all health-care centers, four were chosen by simple random sampling. Nasal samples were cultured in blood agar medium for S. aureus and antibiotic susceptibility profile was determined by disc diffusion and E-test. Risk factors for nasal carriage of MDRSA were also determined. Results: A total of 92 (26.3) S. aureus isolates were obtained, of which 33 (35.9) were MRSA and 27 (29.3) were MDRSA. Of MRSA strains, 19 (70.4) were MDRSA. S. aureus isolates showed 52.2 resistance to cephalothin, 33.7 to co-trimoxazole, 26.1 to clindamycin, 26.1 to ciprofloxacin, 4.3 to vancomycin, and 35.9 to oxacillin. The risk factors for nasal carriage of MDRSA were antibiotic usage during the last three months (P = 0.006), family size of more than four members (P = 0.044), and parental smoking (P = 0.045). Conclusions: MDRSA was not uncommon among healthy children in Kashan and prevention of its spread in the population is judicious. © 2014, Iranian Red Crescent Medical Journal.

Item Type: Article
Additional Information: cited By 8
Subjects: Immunology and Microbiology
Divisions: Faculty of Medicine > Clinical Sciences > Department of Pediatrics
Depositing User: editor . 2
Date Deposited: 06 Mar 2017 16:27
Last Modified: 03 Jun 2017 13:49
URI: http://eprints.kaums.ac.ir/id/eprint/405

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