The effects of vitamin D and probiotic co-supplementation on glucose homeostasis, inflammation, oxidative stress and pregnancy outcomes in gestational diabetes: A randomized, double-blind, placebo-controlled trial

Jamilian, M. and Amirani, E. and Asemi, Z. (2018) The effects of vitamin D and probiotic co-supplementation on glucose homeostasis, inflammation, oxidative stress and pregnancy outcomes in gestational diabetes: A randomized, double-blind, placebo-controlled trial. Clinical Nutrition.

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Abstract

Background and aims: This study was designed to assess the effects of combined vitamin D and probiotic supplementation on metabolic status and pregnancy outcomes in women with gestational diabetes (GDM). Methods: This randomized, double-blind, placebo-controlled clinical trial was performed in 87 women with GDM. Patients were randomly assigned three groups to receive either vitamin D (50,000 IU/every 2 weeks) plus probiotic (8 � 109 CFU/day) (n = 30), probiotic (8 � 109 CFU/day) (n = 29) or placebo (n = 28) for 6 weeks. Results: Vitamin D and probiotic co-supplementation significantly reduced fasting plasma glucose (β �10.99 mg/dL; 95 CI, �14.26, �7.73; P < 0.001), serum insulin levels (β �1.95 μIU/mL; 95 CI, �3.05, �0.84; P = 0.001) and homeostasis model of assessment-insulin resistance (β �0.76; 95 CI, �1.06, �0.45; P < 0.001), and significantly increased the quantitative insulin sensitivity check index (β 0.01; 95 CI, 0.008, 0.03; P = 0.001) compared with the placebo. In addition, vitamin D and probiotic co-supplementation resulted in a significant reduction in triglycerides (β �37.56 mg/dL; 95 CI, �51.55, �23.56; P < 0.001), VLDL- (β �7.51 mg/dL; 95 CI, �10.31, �4.71; P < 0.001), HDL-/total cholesterol ratio (β �0.52; 95 CI, �0.79, �0.24; P < 0.001), high sensitivity C-reactive protein (β �1.80 mg/L; 95 CI, �2.53, �1.08; P < 0.001) and malondialdehyde (β �0.43 μmol/L; 95 CI, �0.77, �0.09; P = 0.01); also, a significant rise in HDL-cholesterol (β 4.09 mg/dL; 95 CI, 1.11, 7.08; P = 0.008) and total antioxidant capacity (TAC) levels (β 97.77 mmol/L; 95 CI, 52.34, 143.19; P < 0.001) were observed compared with the placebo. Vitamin D and probiotic co-supplementation did not change other metabolic parameters. Vitamin D and probiotic co-supplementation significantly decreased triglycerides (P = 0.02), VLDL-cholesterol (P = 0.02) and hs-CRP (P = 0.01), and significantly increased TAC (P = 0.006) and total glutathione levels (P = 0.04) compared with only probiotic group. Conclusions: In conclusion, vitamin D and probiotic co-supplementation in women with GDM had beneficial effects on metabolic status. This trial was registered at www.irct.ir as IRCT201706075623N119. © 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism

Item Type: Article
Additional Information: cited By 1; Article in Press
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 14 Apr 2019 08:41
Last Modified: 14 Apr 2019 08:41
URI: http://eprints.kaums.ac.ir/id/eprint/4037

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