The effects of microRNAs in activating neovascularization pathways in diabetic retinopathy

Satari, M. and Aghadavod, E. and Mirhosseini, N. and Asemi, Z. (2018) The effects of microRNAs in activating neovascularization pathways in diabetic retinopathy. Journal of Cellular Biochemistry.

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Abstract

Diabetic retinopathy (DR) is one of the major complications of diabetes mellitus that causes diabetic macular edema and visual loss. DR is categorized, based on the presence of vascular lesions and neovascularization, into non-proliferative and proliferative DR. Vascular changes in DR correlate with the cellular damage and pathological changes in the capillaries of blood-retinal barrier. Several cytokines have been involved in inducing neovascularization. These cytokines activate different signaling pathways which are mainly responsible for the complications of DR. Recently; microRNAs (miRNAs) have been introduced as the key factors in the regulation of the cytokine expression which plays a critical role in neovascularization of retinal cells. Some studies have demonstrated that changing levels of miRNAs have essential role in the pathophysiology of vascular changes in patients with DR. The aim of this study is to identify the effects of miRNAs in the pathogenesis of DR via activating neovascularization pathways. © 2018 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 0; Article in Press
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Biochemistry
Depositing User: ART . editor
Date Deposited: 14 Apr 2019 10:50
Last Modified: 14 Apr 2019 10:50
URI: http://eprints.kaums.ac.ir/id/eprint/4033

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