The Effects of Synbiotic Supplementation on Metabolic Status in Diabetic Patients Undergoing Hemodialysis: a Randomized, Double-Blinded, Placebo-Controlled Trial

Soleimani, A. and Motamedzadeh, A. and Zarrati Mojarrad, M. and Bahmani, F. and Amirani, E. and Ostadmohammadi, V. and Tajabadi-Ebrahimi, M. and Asemi, Z. (2018) The Effects of Synbiotic Supplementation on Metabolic Status in Diabetic Patients Undergoing Hemodialysis: a Randomized, Double-Blinded, Placebo-Controlled Trial. Probiotics and Antimicrobial Proteins.

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Abstract

This study was conducted to evaluate the effects of synbiotic supplementation on metabolic profiles in diabetic patients undergoing hemodialysis (HD). This randomized, double-blinded, placebo-controlled clinical trial was performed in 60 diabetic HD patients. Participants were randomly assigned into two groups to receive either synbiotic capsule, containing Lactobacillus acidophilus, Lactobacillus casei, and Bifidobacterium bifidum (2 � 109 CFU/g each), plus 0.8 g/day of inulin (n = 30) or placebo (n = 30) for 12 weeks. Synbiotic supplementation significantly decreased fasting plasma glucose (β � 13.56 mg/dL; 95 CI, � 23.82, � 3.30; P = 0.01), insulin levels (β � 5.49 μIU/mL; 95 CI, � 6.92, � 4.05; P < 0.001), and insulin resistance (β � 2.25; 95 CI, � 3.02, � 1.48; P < 0.001), while increased the quantitative insulin sensitivity check index (β 0.02; 95 CI, 0.01, 0.02; P < 0.001) compared with the placebo. Additionally, synbiotic intake resulted in a significant reduction in high-sensitivity C-reactive protein (β � 2930.48 ng/mL; 95 CI, � 3741.15, � 2119.80; P < 0.001) and malondialdehyde levels (β � 0.60 μmol/L; 95 CI, � 0.99, � 0.20; P = 0.003). Moreover, we found a significant increase in total antioxidant capacity (β 142.99 mmol/L; 95 CI, 61.72, 224.25; P = 0.001) and total glutathione levels (β 131.11 μmol/L; 95 CI, 89.35, 172.87; P < 0.001) in the synbiotic group compared with the placebo group. Overall, synbiotic supplementation for 12 weeks had beneficial effects on glycemic control, biomarkers of inflammation, and oxidative stress in diabetic patients under HD. This study was registered in the Iranian website (www.irct.ir) for registration of clinical trials (http://www.irct.ir: IRCT2017090133941N17). http://www.irct.ir: IRCT2017090133941N17. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Item Type: Article
Additional Information: cited By 0; Article in Press
Subjects: Endocrinology Metabolism
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Biochemistry
Depositing User: ART . editor
Date Deposited: 14 Apr 2019 10:41
Last Modified: 14 Apr 2019 10:41
URI: http://eprints.kaums.ac.ir/id/eprint/4032

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