Effect of Tranexamic Acid on Prevention of Hemorrhagic Mass Growth in Patients with Traumatic Brain Injury

Fakharian, E. and Abedzadeh-kalahroudi, M. and Atoof, F. (2018) Effect of Tranexamic Acid on Prevention of Hemorrhagic Mass Growth in Patients with Traumatic Brain Injury. World Neurosurgery, 109. e748-e753.

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Abstract

Background Intracranial hemorrhage is a common complication of traumatic brain injury (TBI). The purpose of this study is evaluation of the effect of tranexamic acid (TXA) on hemorrhagic mass growth in TBI patients. Patients and Methods In this randomized, double-blind clinical trial, 149 patients with TBI and any kind of blood on their computed tomography scan enrolled in the study and were randomly allocated to receive TXA or placebo. After 24 hours, computed tomography scan was repeated for assessing the changes in hemorrhage, new bleeding, and mass effects of blood on brain tissue. The primary outcome was growth of the hemorrhagic lesion. Data were analyzed by SPSS software using Fisher exact, chi-square, and Mann-Whitney U tests, as well as linear and logistic regression models. Findings The incidence of hemorrhagic lesion growth was 20.5 in the TXA group and 22.7 in the placebo group. The difference was not significant (P = 0.87, RR = 0.89). The mean (standard deviation) of hemorrhagic lesion growth was 9.4 (15.3) in the TXA group and 10.2 (10.1) in the placebo group without significant difference (P = 0.27). The frequency of deaths (2.7 vs. 4), adverse outcome at discharge (10.8 vs. 17.3), and 3 months later (6.8 vs. 14.7) in the TXA group were lower than the placebo, but the difference was not statistically significant. No side effect was observed with the administration of TXA. Conclusion Administration of a short dose of TXA does not lead to significant prevention of growth of posttraumatic hemorrhagic lesion or improvement of clinical outcomes. © 2017 Elsevier Inc.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: placebo; tranexamic acid; antifibrinolytic agent; tranexamic acid, adult; adverse outcome; Article; brain hemorrhage; brain tissue; clinical outcome; computer assisted tomography; controlled study; contusion; double blind procedure; drug efficacy; epidural hematoma; female; Glasgow outcome scale; hospital discharge; human; human tissue; incidence; major clinical study; male; outcome assessment; randomized controlled trial; subarachnoid hemorrhage; subdural hematoma; traumatic brain injury; brain hemorrhage; complication; diagnostic imaging; follow up; middle aged; traumatic brain injury; young adult, Adult; Antifibrinolytic Agents; Brain Injuries, Traumatic; Double-Blind Method; Female; Follow-Up Studies; Humans; Intracranial Hemorrhages; Male; Middle Aged; Tranexamic Acid; Young Adult
Subjects: Nursing
Divisions: Faculty of Nursing & Midwifery > Department of Nursing - Medical Surgical
Depositing User: ART . editor
Date Deposited: 14 Apr 2019 10:31
Last Modified: 14 Apr 2019 10:31
URI: http://eprints.kaums.ac.ir/id/eprint/4029

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