The effects of omega-3 and vitamin E co-supplementation on carotid intimamedia thickness and inflammatory factors in patients with polycystic ovary syndrome

Talari, H.R. and Poladchang, S. and Hamidian, Y. and Samimi, M. and Gilasi, H.R. and Ebrahimi, F.A. and Asemi, Z. (2018) The effects of omega-3 and vitamin E co-supplementation on carotid intimamedia thickness and inflammatory factors in patients with polycystic ovary syndrome. Oman Medical Journal, 33 (6). pp. 473-479.

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Abstract

Objectives: We sought to evaluate the effects of omega-3 and vitamin E cosupplementation on carotid intima-media thickness (CIMT) and inflammatory factors in patients with polycystic ovary syndrome (PCOS). Methods: This randomized, doubleblind, placebo-controlled trial was done among 60 women with PCOS. Participants were randomly assigned into two groups (n = 30 each group) and assigned to take either 1000 mg omega-3 plus 400 IU vitamin E supplements or a placebo for 12 weeks. Results: Compared with placebo, omega-3 and vitamin E co-supplementation led to significant decreases in maximum levels of left CIMT (-0.006±0.006 vs. +0.002±0.007 mm, p < 0.001), mean levels of left CIMT (-0.005±0.006 vs. +0.002±0.010 mm, p = 0.010), maximum levels of right CIMT (-0.006±0.010 vs. +0.006±0.010 mm, p = 0.010), and mean levels of right CIMT (-0.005±0.005 vs. +0.001±0.010 mm, p = 0.020). Change in high-sensitivity C-reactive protein (hs-CRP) (-390.6±942.9 vs. +237.0±754.3 ng/mL, p = 0.006) was significantly different between the supplemented patients and placebo group. We did not observe any significant effect in plasma nitric oxide (NO) values following supplementation with omega-3 plus vitamin E compared with the placebo. Conclusions: Co-supplementation with omega-3 and vitamin E for 12 weeks among patients with PCOS had beneficial effects on CIMT and serum hs-CRP values, but unchanged NO values. © 2018, Oman Medical Specialty Board. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: alpha tocopherol; C reactive protein; nitric oxide; omega 3 fatty acid; placebo, adult; age; arterial wall thickness; Article; body height; body mass; body weight; carotid artery bifurcation; controlled study; Doppler ultrasonography; double blind procedure; enzyme linked immunosorbent assay; female; human; inflammation; ovary polycystic disease; patient compliance; randomized controlled trial; vitamin supplementation
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 14 Apr 2019 12:35
Last Modified: 14 Apr 2019 12:35
URI: http://eprints.kaums.ac.ir/id/eprint/4021

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