The correlation between the numerical status of Th22 cells and serum level of IL-22 with severity of ulcerative colitis

Arj, A. and Razavizadeh, M. and Mohammadi, H. and Nikoueinejad, H. and Akbari, H. (2018) The correlation between the numerical status of Th22 cells and serum level of IL-22 with severity of ulcerative colitis. Iranian Journal of Allergy, Asthma and Immunology, 17 (1). pp. 78-84.

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Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease, yet its etiology as well as pathogenesis remains poorly understood. There is increasing evidence that aberrant expression of CD4+T lymphocytes plays an essential role in the progression of different pathologies such as UC. This study aimed to evaluate the circulatory frequency of T-helper 22 (Th22), a subset of CD4+ T cells, and serum level of its signature cytokine, IL-22, in patients with UC. Blood samples from 30 patients with UC and 30 controls (n=30) were tested for IL-22 level and circulatory Th22-cell count by ELISA and Flow cytometric analysis, respectively. Our results revealed higher serum level of IL-22 as well as circulatory frequency of Th22 cells in patients with UC compared to those in healthy controls. Notably, effective factors on severity of the disease were age, Th22, IL-22, ESR and CRP. We conclude that elevated circulating Th22 cells and their signature cytokine, IL-22, may be implicated in the pathogenesis of UC. These findings may provide preliminary experimental clues for the development of new therapies for UC and its severity judgment. © February 2018, Iran J Allergy Asthma Immunol. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: C reactive protein; interleukin 22, adult; age; Article; blood sampling; clinical article; controlled study; disease association; disease severity; enzyme linked immunosorbent assay; erythrocyte sedimentation rate; female; flow cytometry; human; male; pathogenesis; protein blood level; Th22 cell; ulcerative colitis
Subjects: Medicine
Divisions: Faculty of Medicine > Clinical Sciences > Department of Internal Medicine
Depositing User: ART . editor
Date Deposited: 15 Apr 2019 12:42
Last Modified: 15 Apr 2019 12:42

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